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PA3720 PA3720 armR armR nalC nalC mexR mexR nalD nalD oprM oprM mexA mexA PA3718 PA3718
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PA3720Hypothetical protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (141 aa)    
Predicted Functional Partners:
armR
Antirepressor for MexR, ArmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
  
  
 0.993
nalC
NalC; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
  
  
 0.984
mexR
Multidrug resistance operon repressor MexR; Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon.
   
  
 0.882
nalD
NalD; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
      
 0.824
oprM
Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane co [...]
      
 0.768
mexA
Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
      
 0.691
PA3718
Probable major facilitator superfamily (MFS) transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
    0.493
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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