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nalC nalC PA3720 PA3720 armR armR mexT mexT mexR mexR oprM oprM nalD nalD mexA mexA nfxB nfxB oprN oprN oprJ oprJ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nalCNalC; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (213 aa)    
Predicted Functional Partners:
PA3720
Hypothetical protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
  
  
 0.984
armR
Antirepressor for MexR, ArmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
  
  
 0.965
mexT
Transcriptional regulator MexT; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
    
 
 0.885
mexR
Multidrug resistance operon repressor MexR; Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon.
   
  
 0.884
oprM
Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane co [...]
     
 0.883
nalD
NalD; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
   
  
 0.883
mexA
Resistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexA precursor; The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
      
 0.881
nfxB
Transcriptional regulator NfxB; Confers resistance to guinolones. May negatively regulate the expression of genes that are associated with cell permeability to drugs.
      
 0.881
oprN
Multidrug efflux outer membrane protein OprN precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
     
 0.880
oprJ
Multidrug efflux outer membrane protein OprJ precursor; Channel-forming component of a multidrug resistance efflux pump; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
     
 0.880
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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