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pepA pepA pepN pepN gshB gshB holC holC PA0164 PA0164 gshA gshA PA0361 PA0361 ggt ggt PA2181 PA2181 glyA3 glyA3 cysK cysK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pepALeucine aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity). (495 aa)    
Predicted Functional Partners:
pepN
Product name confidence: Class 2 (High similarity to functionally studied protein).
  
 0.988
gshB
Glutathione synthetase; Product name confidence: Class 2 (High similarity to functionally studied protein).
   
 
 0.957
holC
DNA polymerase III, chi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
  
  
 0.932
PA0164
Probable gamma-glutamyltranspeptidase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
  
 0.925
gshA
Glutamate--cysteine ligase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
   
 
 0.915
PA0361
Probable gamma-glutamyltranspeptidase precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
     
 0.912
ggt
Gamma-glutamyltranspeptidase precursor; Product name confidence: Class 2 (High similarity to functionally studied protein).
   
 
 0.912
PA2181
Hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
     
  0.900
glyA3
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.831
cysK
Cysteine synthase A; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 0.830
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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