node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA0127 | dauR | PA0127 | PA3864 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Transcriptional regulator of the dauBAR operon, DauR; DauR represses the dauBAR operon. Belongs to the DauR family. | 0.407 |
PA0127 | opdP | PA0127 | PA4501 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Glycine-glutamate dipeptide porin OpdP; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.504 |
PA1314 | PA5099 | PA1314 | PA5099 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Probable transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the purine-cytosine permease (2.A.39) family. | 0.525 |
PA1314 | dauR | PA1314 | PA3864 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Transcriptional regulator of the dauBAR operon, DauR; DauR represses the dauBAR operon. Belongs to the DauR family. | 0.431 |
PA1314 | opdP | PA1314 | PA4501 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Glycine-glutamate dipeptide porin OpdP; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.519 |
PA2576 | dauR | PA2576 | PA3864 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Transcriptional regulator of the dauBAR operon, DauR; DauR represses the dauBAR operon. Belongs to the DauR family. | 0.501 |
PA3893 | dauR | PA3893 | PA3864 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Transcriptional regulator of the dauBAR operon, DauR; DauR represses the dauBAR operon. Belongs to the DauR family. | 0.417 |
PA3893 | opdP | PA3893 | PA4501 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Glycine-glutamate dipeptide porin OpdP; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.715 |
PA5099 | PA1314 | PA5099 | PA1314 | Probable transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the purine-cytosine permease (2.A.39) family. | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | 0.525 |
PA5099 | dauR | PA5099 | PA3864 | Probable transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the purine-cytosine permease (2.A.39) family. | Transcriptional regulator of the dauBAR operon, DauR; DauR represses the dauBAR operon. Belongs to the DauR family. | 0.448 |
PA5099 | opdP | PA5099 | PA4501 | Probable transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the purine-cytosine permease (2.A.39) family. | Glycine-glutamate dipeptide porin OpdP; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.494 |
argR | dauA | PA0893 | PA3863 | Transcriptional regulator ArgR; ArgR could be a transcriptional activator of the dauBAR operon in response to the presence of L-Arg. | FAD-dependent catabolic D-arginine dehydrogenase, DauA; DauA is highly expressed within the cystic fibrosis (CF) lung, and it is required for virulence via the optimal production of hydrogen cyanide, pyocyanine, pyoverdine, rhamnolipid and alginate during biofilm formation. Involved in the catabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, [...] | 0.493 |
argR | dauB | PA0893 | PA3862 | Transcriptional regulator ArgR; ArgR could be a transcriptional activator of the dauBAR operon in response to the presence of L-Arg. | NAD(P)H-dependent anabolic L-arginine dehydrogenase, DauB; Involved in the anabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, before to be channeled into the AST and/or ATA pathways. DauB catalyzes the synthesis of L-arginine from 2-ketoarginine (2-KA) and ammonium. | 0.570 |
argR | dauR | PA0893 | PA3864 | Transcriptional regulator ArgR; ArgR could be a transcriptional activator of the dauBAR operon in response to the presence of L-Arg. | Transcriptional regulator of the dauBAR operon, DauR; DauR represses the dauBAR operon. Belongs to the DauR family. | 0.803 |
dauA | argR | PA3863 | PA0893 | FAD-dependent catabolic D-arginine dehydrogenase, DauA; DauA is highly expressed within the cystic fibrosis (CF) lung, and it is required for virulence via the optimal production of hydrogen cyanide, pyocyanine, pyoverdine, rhamnolipid and alginate during biofilm formation. Involved in the catabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, [...] | Transcriptional regulator ArgR; ArgR could be a transcriptional activator of the dauBAR operon in response to the presence of L-Arg. | 0.493 |
dauA | dauB | PA3863 | PA3862 | FAD-dependent catabolic D-arginine dehydrogenase, DauA; DauA is highly expressed within the cystic fibrosis (CF) lung, and it is required for virulence via the optimal production of hydrogen cyanide, pyocyanine, pyoverdine, rhamnolipid and alginate during biofilm formation. Involved in the catabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, [...] | NAD(P)H-dependent anabolic L-arginine dehydrogenase, DauB; Involved in the anabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, before to be channeled into the AST and/or ATA pathways. DauB catalyzes the synthesis of L-arginine from 2-ketoarginine (2-KA) and ammonium. | 0.999 |
dauA | dauR | PA3863 | PA3864 | FAD-dependent catabolic D-arginine dehydrogenase, DauA; DauA is highly expressed within the cystic fibrosis (CF) lung, and it is required for virulence via the optimal production of hydrogen cyanide, pyocyanine, pyoverdine, rhamnolipid and alginate during biofilm formation. Involved in the catabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, [...] | Transcriptional regulator of the dauBAR operon, DauR; DauR represses the dauBAR operon. Belongs to the DauR family. | 0.971 |
dauA | rhl | PA3863 | PA3861 | FAD-dependent catabolic D-arginine dehydrogenase, DauA; DauA is highly expressed within the cystic fibrosis (CF) lung, and it is required for virulence via the optimal production of hydrogen cyanide, pyocyanine, pyoverdine, rhamnolipid and alginate during biofilm formation. Involved in the catabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, [...] | ATP-dependent RNA helicase RhlB; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. | 0.537 |
dauB | argR | PA3862 | PA0893 | NAD(P)H-dependent anabolic L-arginine dehydrogenase, DauB; Involved in the anabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, before to be channeled into the AST and/or ATA pathways. DauB catalyzes the synthesis of L-arginine from 2-ketoarginine (2-KA) and ammonium. | Transcriptional regulator ArgR; ArgR could be a transcriptional activator of the dauBAR operon in response to the presence of L-Arg. | 0.570 |
dauB | dauA | PA3862 | PA3863 | NAD(P)H-dependent anabolic L-arginine dehydrogenase, DauB; Involved in the anabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, before to be channeled into the AST and/or ATA pathways. DauB catalyzes the synthesis of L-arginine from 2-ketoarginine (2-KA) and ammonium. | FAD-dependent catabolic D-arginine dehydrogenase, DauA; DauA is highly expressed within the cystic fibrosis (CF) lung, and it is required for virulence via the optimal production of hydrogen cyanide, pyocyanine, pyoverdine, rhamnolipid and alginate during biofilm formation. Involved in the catabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, [...] | 0.999 |