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sltB1 sltB1 pbpA pbpA rlpA rlpA mltD mltD mltF mltF rlpA-2 rlpA-2 rodA rodA mltG mltG dacC dacC ampDh2 ampDh2 ampDh3 ampDh3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sltB1Soluble lytic transglycosylase B; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (340 aa)    
Predicted Functional Partners:
pbpA
Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall.
  
 
 0.982
rlpA
Hypothetical protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides; Belongs to the RlpA family.
 
  
 0.965
mltD
Membrane-bound lytic murein transglycosylase D precursor; Product name confidence: Class 2 (High similarity to functionally studied protein).
   
  
 0.924
mltF
Conserved hypothetical protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family.
   
  
 0.899
rlpA-2
Conserved hypothetical protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
  
  
 0.893
rodA
Rod shape-determining protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.
  
  
 0.868
mltG
Conserved hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.
  
  
 0.803
dacC
D-ala-D-ala-carboxypeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S11 family.
 
  
 0.799
ampDh2
AmpDh2; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
  
 0.783
ampDh3
AmpDh3; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
      
 0.781
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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