node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA0190 | PA5281 | PA0190 | PA5281 | Probable acid phosphatase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.909 |
PA0190 | hpaC | PA0190 | PA4092 | Probable acid phosphatase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 4-hydroxyphenylacetate 3-monooxygenase small chain; Reductase component of the 4-hydroxyphenylacetate (HPA) 3- hydroxylase. Catalyzes the reduction of FAD by NADH. The reduced flavin is then transferred to the oxygenase component HpaB. Is also able to reduce FMN and riboflavin, but preferentially binds FAD. Has no activity with NADPH as the reductant; Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily. | 0.904 |
PA0190 | ribC | PA0190 | PA4055 | Probable acid phosphatase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Riboflavin synthase alpha chain; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.901 |
PA0190 | ribF | PA0190 | PA4561 | Probable acid phosphatase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Riboflavin kinase/FAD synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the ribF family. | 0.901 |
PA5281 | PA0190 | PA5281 | PA0190 | Probable hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable acid phosphatase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.909 |
PA5281 | hpaC | PA5281 | PA4092 | Probable hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 4-hydroxyphenylacetate 3-monooxygenase small chain; Reductase component of the 4-hydroxyphenylacetate (HPA) 3- hydroxylase. Catalyzes the reduction of FAD by NADH. The reduced flavin is then transferred to the oxygenase component HpaB. Is also able to reduce FMN and riboflavin, but preferentially binds FAD. Has no activity with NADPH as the reductant; Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily. | 0.903 |
PA5281 | ribB | PA5281 | PA4054 | Probable hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.407 |
PA5281 | ribC | PA5281 | PA4055 | Probable hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Riboflavin synthase alpha chain; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.908 |
PA5281 | ribD | PA5281 | PA4056 | Probable hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Riboflavin-specific deaminase/reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.946 |
PA5281 | ribE | PA5281 | PA4053 | Probable hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.908 |
PA5281 | ribF | PA5281 | PA4561 | Probable hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Riboflavin kinase/FAD synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the ribF family. | 0.919 |
aroQ2 | ribC | PA0245 | PA4055 | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. | Riboflavin synthase alpha chain; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.706 |
folB | ribA | PA0582 | PA4047 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. | 0.463 |
folB | ribB | PA0582 | PA4054 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. | 0.463 |
folB | ribC | PA0582 | PA4055 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Riboflavin synthase alpha chain; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.694 |
folB | ribD | PA0582 | PA4056 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Riboflavin-specific deaminase/reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.784 |
folB | ribE | PA0582 | PA4053 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.481 |
folB | ribF | PA0582 | PA4561 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Riboflavin kinase/FAD synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the ribF family. | 0.773 |
hpaC | PA0190 | PA4092 | PA0190 | 4-hydroxyphenylacetate 3-monooxygenase small chain; Reductase component of the 4-hydroxyphenylacetate (HPA) 3- hydroxylase. Catalyzes the reduction of FAD by NADH. The reduced flavin is then transferred to the oxygenase component HpaB. Is also able to reduce FMN and riboflavin, but preferentially binds FAD. Has no activity with NADPH as the reductant; Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily. | Probable acid phosphatase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.904 |
hpaC | PA5281 | PA4092 | PA5281 | 4-hydroxyphenylacetate 3-monooxygenase small chain; Reductase component of the 4-hydroxyphenylacetate (HPA) 3- hydroxylase. Catalyzes the reduction of FAD by NADH. The reduced flavin is then transferred to the oxygenase component HpaB. Is also able to reduce FMN and riboflavin, but preferentially binds FAD. Has no activity with NADPH as the reductant; Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily. | Probable hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.903 |