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PA4088 PA4088 hemA hemA hemB hemB hemL hemL PA5523 PA5523 PA0221 PA0221 spuC spuC PA4087 PA4087 PA4089 PA4089 mdlC mdlC hemC hemC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PA4088Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)    
Predicted Functional Partners:
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.987
hemB
Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family.
 
 
 0.967
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
  
  
0.932
PA5523
Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
0.909
PA0221
Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.886
spuC
Putrescine aminotransferase; Involved in the putrescine catabolism. Catalyzes the transfer of the amino group from putrescine to pyruvate to yield 4-aminobutanal and alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
   
 0.826
PA4087
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
  
  
 0.783
PA4089
Probable short-chain dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
  
 0.783
mdlC
Benzoylformate decarboxylase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the TPP enzyme family.
   
  
 0.741
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.712
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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