STRINGSTRING
ampR ampR ampC ampC nagZ nagZ ampG ampG ampD ampD ampDh3 ampDh3 ampDh2 ampDh2 oprD oprD nalD nalD mexR mexR mexT mexT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ampRTranscriptional regulator AmpR; This protein is a positive regulator of gene expression of beta-lactamase (AmpC); Belongs to the LysR transcriptional regulatory family. (296 aa)    
Predicted Functional Partners:
ampC
Beta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family.
     
 0.941
nagZ
beta-N-acetyl-D-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides (By similarity). Contributes to intrinsic fosfomycin resistance in P.aeruginosa ; Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
      
 0.884
ampG
AmpG; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
      
 0.883
ampD
Beta-lactamase expression regulator AmpD; Product name confidence: Class 2 (High similarity to functionally studied protein).
      
 0.883
ampDh3
AmpDh3; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
      
 0.881
ampDh2
AmpDh2; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
      
 0.881
oprD
Basic amino acid, basic peptide and imipenem outer membrane porin OprD precursor; Porin with a specificity for basic amino acids. Also possesses serine protease activity; Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.
      
 0.808
nalD
NalD; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
    
 
 0.778
mexR
Multidrug resistance operon repressor MexR; Repressor of the mexAB-oprM multidrug resistance operon. Also represses its own expression. Many variants lead to increased expression of the mexAB-oprM operon.
   
  
 0.771
mexT
Transcriptional regulator MexT; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
      
 0.768
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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