STRINGSTRING
hpcB hpcB hpcC hpcC hpcD hpcD PA4122 PA4122 PA4128 PA4128 hpcG hpcG PA4121 PA4121 hpaA hpaA PA4120 PA4120 hpaC hpaC PA4126 PA4126
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hpcBHomoprotocatechuate 2,3-dioxygenase; Product name confidence: Class 2 (High similarity to functionally studied protein). (307 aa)    
Predicted Functional Partners:
hpcC
5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the aldehyde dehydrogenase family.
 
 
 0.999
hpcD
5-carboxymethyl-2-hydroxymuconate isomerase; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
  
 0.998
PA4122
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
 
  
 0.993
PA4128
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences); Belongs to the HpcH/HpaI aldolase family.
 
  
 0.993
hpcG
2-oxo-hept-3-ene-1,7-dioate hydratase; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
  
 0.989
PA4121
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
 
  
 0.975
hpaA
4-hydroxyphenylacetate 3-monooxygenase large chain; Oxygenase component of the 4-hydroxyphenylacetate (HPA) 3- hydroxylase. Catalyzes the hydroxylation of 4-hydroxyphenylacetate to form 3,4-dihydroxyphenylacetate, using FADH(-) provided by the reductase component HpaC to activate oxygen. To a lesser extent, can also use reduced FMN. In vitro, has hydroxylation activity toward tyrosol and various cinnamic acid derivatives, catalyzing the hydroxylation of p-coumaric acid, caffeic acid, ferulic acid, and coniferaldehyde.
 
 
 0.966
PA4120
Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
  
 0.963
hpaC
4-hydroxyphenylacetate 3-monooxygenase small chain; Reductase component of the 4-hydroxyphenylacetate (HPA) 3- hydroxylase. Catalyzes the reduction of FAD by NADH. The reduced flavin is then transferred to the oxygenase component HpaB. Is also able to reduce FMN and riboflavin, but preferentially binds FAD. Has no activity with NADPH as the reductant; Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily.
 
 
 0.954
PA4126
Probable major facilitator superfamily (MFS) transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
    0.936
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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