node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA4171 | PA4172 | PA4171 | PA4172 | Probable protease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.845 |
PA4172 | PA4171 | PA4172 | PA4171 | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable protease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.845 |
PA4172 | birA | PA4172 | PA4280 | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.776 |
PA4172 | crc | PA4172 | PA5332 | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Catabolite repression control protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.927 |
PA4172 | dnaN | PA4172 | PA0002 | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.730 |
PA4172 | gpuP | PA4172 | PA0287 | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 3-guanidinopropionate transport protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.774 |
PA4172 | ligD | PA4172 | PA2138 | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable ATP-dependent DNA ligase; With Ku probably forms a non-homologous end joining (NHEJ) repair enzyme, which repairs dsDNA breaks (DSB) with reduced fidelity. Acts as a DNA ligase on singly nicked dsDNA, fills dsDNA gaps (3- or 4- nucleotide gaps, prefers a 5'-phosphate at the gap distal end, prefers dNTPs over rNTPs) , has DNA-directed DNA polymerase activity (templated primer extension) and DNA-directed RNA polymerase activity , adds 1 or 2 non-templated rNTP (or less well dNTP) to ssDNA or blunt-end dsDNA (primer extension). Has 3' resection activity, removing 3'-rNMPs from DN [...] | 0.773 |
PA4172 | mutY | PA4172 | PA5147 | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | A / G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.703 |
PA4172 | nth | PA4172 | PA3495 | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.734 |
PA4172 | polA | PA4172 | PA5493 | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.770 |
PA4172 | xthA | PA4172 | PA2545 | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Exodeoxyribonuclease III; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.925 |
birA | PA4172 | PA4280 | PA4172 | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.776 |
birA | crc | PA4280 | PA5332 | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Catabolite repression control protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.778 |
birA | mutY | PA4280 | PA5147 | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | A / G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.555 |
birA | xthA | PA4280 | PA2545 | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Exodeoxyribonuclease III; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.776 |
crc | PA4172 | PA5332 | PA4172 | Catabolite repression control protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Probable nuclease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.927 |
crc | birA | PA5332 | PA4280 | Catabolite repression control protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.778 |
crc | dnaN | PA5332 | PA0002 | Catabolite repression control protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.735 |
crc | ligD | PA5332 | PA2138 | Catabolite repression control protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | Probable ATP-dependent DNA ligase; With Ku probably forms a non-homologous end joining (NHEJ) repair enzyme, which repairs dsDNA breaks (DSB) with reduced fidelity. Acts as a DNA ligase on singly nicked dsDNA, fills dsDNA gaps (3- or 4- nucleotide gaps, prefers a 5'-phosphate at the gap distal end, prefers dNTPs over rNTPs) , has DNA-directed DNA polymerase activity (templated primer extension) and DNA-directed RNA polymerase activity , adds 1 or 2 non-templated rNTP (or less well dNTP) to ssDNA or blunt-end dsDNA (primer extension). Has 3' resection activity, removing 3'-rNMPs from DN [...] | 0.658 |
crc | mutY | PA5332 | PA5147 | Catabolite repression control protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | A / G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.712 |