Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aprA | cbpD | PA1249 | PA0852 | Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family. | Chitin-binding protein CbpD precursor; Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity. | 0.713 |
| aprA | impA | PA1249 | PA0572 | Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family. | Hypothetical protein; Protease that degrades several proteins of the host immune system. Cleaves P-selectin glycoprotein ligand-1 (PSGL-1), leading to its functional inhibition; PSGL-1 is a leukocyte cell-surface receptor essential for leukocyte recruitment to the site of infection. Next to PSGL-1, targets host CD43 and CD44 that are also involved in leukocyte homing. Thus, prevents neutrophil extravasation and thereby protects P.aeruginosa from neutrophil attack. Is also able to inhibit the decay accelerating factor (CD55), but not the cell-surface receptors CD46 and CD31; Belongs to [...] | 0.760 |
| aprA | lap | PA1249 | PA2939 | Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family. | Probable aminopeptidase; A secreted aminopeptidase. Acts on free N-terminal amino groups with a very strong preference for Leu- followed by Met- and Ala-, and no activity on Glu- or Gly- peptides (an exhaustive analysis was not performed). Both the AP56 and AP28 forms have activity. | 0.789 |
| aprA | lasA | PA1249 | PA1871 | Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family. | LasA protease precursor; Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a [...] | 0.907 |
| aprA | lasB | PA1249 | PA3724 | Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family. | Elastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections. | 0.918 |
| aprA | piv | PA1249 | PA4175 | Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family. | Protease IV; Lysine-specific endoprotease. Involved in corneal virulence; Belongs to the peptidase S1 family. | 0.906 |
| aprA | pvdS | PA1249 | PA2426 | Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family. | Sigma factor PvdS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the sigma-70 factor family. ECF subfamily. | 0.509 |
| aprA | toxA | PA1249 | PA1148 | Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family. | Exotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38. | 0.882 |
| cbpD | aprA | PA0852 | PA1249 | Chitin-binding protein CbpD precursor; Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity. | Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family. | 0.713 |
| cbpD | impA | PA0852 | PA0572 | Chitin-binding protein CbpD precursor; Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity. | Hypothetical protein; Protease that degrades several proteins of the host immune system. Cleaves P-selectin glycoprotein ligand-1 (PSGL-1), leading to its functional inhibition; PSGL-1 is a leukocyte cell-surface receptor essential for leukocyte recruitment to the site of infection. Next to PSGL-1, targets host CD43 and CD44 that are also involved in leukocyte homing. Thus, prevents neutrophil extravasation and thereby protects P.aeruginosa from neutrophil attack. Is also able to inhibit the decay accelerating factor (CD55), but not the cell-surface receptors CD46 and CD31; Belongs to [...] | 0.908 |
| cbpD | lap | PA0852 | PA2939 | Chitin-binding protein CbpD precursor; Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity. | Probable aminopeptidase; A secreted aminopeptidase. Acts on free N-terminal amino groups with a very strong preference for Leu- followed by Met- and Ala-, and no activity on Glu- or Gly- peptides (an exhaustive analysis was not performed). Both the AP56 and AP28 forms have activity. | 0.854 |
| cbpD | lasA | PA0852 | PA1871 | Chitin-binding protein CbpD precursor; Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity. | LasA protease precursor; Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a [...] | 0.944 |
| cbpD | lasB | PA0852 | PA3724 | Chitin-binding protein CbpD precursor; Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity. | Elastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections. | 0.965 |
| cbpD | piv | PA0852 | PA4175 | Chitin-binding protein CbpD precursor; Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity. | Protease IV; Lysine-specific endoprotease. Involved in corneal virulence; Belongs to the peptidase S1 family. | 0.834 |
| cbpD | toxA | PA0852 | PA1148 | Chitin-binding protein CbpD precursor; Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity. | Exotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38. | 0.590 |
| fpvA | fpvR | PA2398 | PA2388 | Ferripyoverdine receptor; Receptor for the siderophore ferripyoverdine. | FpvR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. | 0.979 |
| fpvA | piv | PA2398 | PA4175 | Ferripyoverdine receptor; Receptor for the siderophore ferripyoverdine. | Protease IV; Lysine-specific endoprotease. Involved in corneal virulence; Belongs to the peptidase S1 family. | 0.810 |
| fpvA | pvdS | PA2398 | PA2426 | Ferripyoverdine receptor; Receptor for the siderophore ferripyoverdine. | Sigma factor PvdS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the sigma-70 factor family. ECF subfamily. | 0.938 |
| fpvA | toxA | PA2398 | PA1148 | Ferripyoverdine receptor; Receptor for the siderophore ferripyoverdine. | Exotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38. | 0.768 |
| fpvR | fpvA | PA2388 | PA2398 | FpvR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. | Ferripyoverdine receptor; Receptor for the siderophore ferripyoverdine. | 0.979 |
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