node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
phzA1 | phzB1 | PA4210 | PA4211 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzA1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzB1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth; Belongs to the PhzA/PhzB family. | 0.952 |
phzA1 | phzC2 | PA4210 | PA1901 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzA1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. | Phenazine biosynthesis protein PhzC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.947 |
phzA1 | phzD2 | PA4210 | PA1902 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzA1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. | Phenazine biosynthesis protein PhzD; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzD1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. Catalyzes the hydrolysis of the vinyl ether functional group of 2-amino-2-deoxyisochorismate (ADIC), yielding pyruvate and trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA). Also able to act on isochorismate, chorismate and 4-amino-4-deoxychorismate (ADC) as substrates ; Belongs to the isochorismatase family. | 0.941 |
phzA1 | phzE2 | PA4210 | PA1903 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzA1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. | Phenazine biosynthesis protein PhzE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.949 |
phzA1 | phzF2 | PA4210 | PA1904 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzA1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. | Probable phenazine biosynthesis protein; Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known. | 0.994 |
phzA1 | phzG2 | PA4210 | PA1905 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzA1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. | Probable pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | 0.994 |
phzA1 | phzH | PA4210 | PA0051 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzA1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. | Potential phenazine-modifying enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.826 |
phzA1 | phzM | PA4210 | PA4209 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzA1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. | Probable phenazine-specific methyltransferase; Involved in the biosynthesis of pyocyanine, a blue-pigmented phenazine derivative, which plays a role in virulence. Converts phenazine-1-carboxylate (PCA) to 5-methylphenazine-1-carboxylate (5- methyl-PCA); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. | 0.970 |
phzA1 | phzS | PA4210 | PA4217 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzA1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. | Flavin-containing monooxygenase; Involved in the biosynthesis of pyocyanine, a blue-pigmented phenazine derivative, which plays a role in virulence. Catalyzes the oxidative decarboxylation of 5-methylphenazine-1-carboxylate (5-methyl- PCA) to pyocyanine. Can also act on phenazine-1-carboxylate (PCA), converting it into 1-hydroxyphenazine (1-HP). However, PCA is a poor substrate. | 0.979 |
phzA2 | phzC2 | PA1899 | PA1901 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. PhzA2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development. | Phenazine biosynthesis protein PhzC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.827 |
phzA2 | phzD2 | PA1899 | PA1902 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. PhzA2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development. | Phenazine biosynthesis protein PhzD; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzD1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. Catalyzes the hydrolysis of the vinyl ether functional group of 2-amino-2-deoxyisochorismate (ADIC), yielding pyruvate and trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA). Also able to act on isochorismate, chorismate and 4-amino-4-deoxychorismate (ADC) as substrates ; Belongs to the isochorismatase family. | 0.831 |
phzA2 | phzE2 | PA1899 | PA1903 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. PhzA2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development. | Phenazine biosynthesis protein PhzE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.840 |
phzA2 | phzF2 | PA1899 | PA1904 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. PhzA2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development. | Probable phenazine biosynthesis protein; Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known. | 0.985 |
phzA2 | phzG2 | PA1899 | PA1905 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. PhzA2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development. | Probable pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | 0.993 |
phzA2 | phzH | PA1899 | PA0051 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. PhzA2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development. | Potential phenazine-modifying enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.829 |
phzA2 | phzM | PA1899 | PA4209 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. PhzA2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development. | Probable phenazine-specific methyltransferase; Involved in the biosynthesis of pyocyanine, a blue-pigmented phenazine derivative, which plays a role in virulence. Converts phenazine-1-carboxylate (PCA) to 5-methylphenazine-1-carboxylate (5- methyl-PCA); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. | 0.883 |
phzA2 | phzS | PA1899 | PA4217 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. PhzA2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development. | Flavin-containing monooxygenase; Involved in the biosynthesis of pyocyanine, a blue-pigmented phenazine derivative, which plays a role in virulence. Catalyzes the oxidative decarboxylation of 5-methylphenazine-1-carboxylate (5-methyl- PCA) to pyocyanine. Can also act on phenazine-1-carboxylate (PCA), converting it into 1-hydroxyphenazine (1-HP). However, PCA is a poor substrate. | 0.883 |
phzB1 | phzA1 | PA4211 | PA4210 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzB1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth; Belongs to the PhzA/PhzB family. | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzA1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. | 0.952 |
phzB1 | phzC2 | PA4211 | PA1901 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzB1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth; Belongs to the PhzA/PhzB family. | Phenazine biosynthesis protein PhzC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.957 |
phzB1 | phzD2 | PA4211 | PA1902 | Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzB1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth; Belongs to the PhzA/PhzB family. | Phenazine biosynthesis protein PhzD; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzD1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. Catalyzes the hydrolysis of the vinyl ether functional group of 2-amino-2-deoxyisochorismate (ADIC), yielding pyruvate and trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA). Also able to act on isochorismate, chorismate and 4-amino-4-deoxychorismate (ADC) as substrates ; Belongs to the isochorismatase family. | 0.943 |