STRINGSTRING
pchD pchD pchE pchE pchC pchC pchB pchB pchA pchA pchF pchF pchG pchG fptA fptA PA2412 PA2412 PA3327 PA3327 phzD2 phzD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
pchDPyochelin biosynthesis protein PchD; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (547 aa)    
Predicted Functional Partners:
pchE
Dihydroaeruginoic acid synthetase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
0.999
pchC
Pyochelin biosynthetic protein PchC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.999
pchB
Salicylate biosynthesis protein PchB; Involved in the incorporation of salicylate into the siderophore pyochelin. Catalyzes the elimination of the enolpyruvyl side chain from isochorismate to yield salicylate and pyruvate via a rare pericyclic hydrogen transfer mechanism from C2 to C5. PchB also catalyzes the nonphysiological Claisen rearrangement of chorismate to prephenate in which the pyruvylenol tail is transferred from a C3 ether linkage to a C1-C9 linkage.
 
  
 0.999
pchA
Salicylate biosynthesis isochorismate synthase; Involved in the conversion of chorismate to salicylate.
  
 0.999
pchF
Pyochelin synthetase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
  
0.997
pchG
Pyochelin biosynthetic protein PchG; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.995
fptA
Fe(III)-pyochelin outer membrane receptor precursor; High-affinity outer membrane receptor required for the transport of Fe(3+)-pyochelin.
 
  
 0.994
PA2412
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
 
  
 0.978
PA3327
Probable non-ribosomal peptide synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
  
0.976
phzD2
Phenazine biosynthesis protein PhzD; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzD1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. Catalyzes the hydrolysis of the vinyl ether functional group of 2-amino-2-deoxyisochorismate (ADIC), yielding pyruvate and trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA). Also able to act on isochorismate, chorismate and 4-amino-4-deoxychorismate (ADC) as substrates ; Belongs to the isochorismatase family.
 
 
 0.973
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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