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PA4292 PA4292 glpT glpT pstA pstA pstS pstS phoA2 phoA2 phoU phoU phoR phoR PA5130 PA5130 PA3576 PA3576 ppx ppx PA5208 PA5208
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PA4292Probable phosphate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (489 aa)    
Predicted Functional Partners:
glpT
Glycerol-3-phosphate transporter; Product name confidence: Class 2 (High similarity to functionally studied protein).
   
  
 0.886
pstA
Membrane protein component of ABC phosphate transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
     
 0.884
pstS
Phosphate ABC transporter, periplasmic phosphate-binding protein, PstS; Binds 1 inorganic phosphate per subunit with a KD of 0.34 uM. Required for phosphate transport. In strain PAO1 implicated in host cell adhesion; in some virulent strains (e.g. MDR25 which expresses very high levels of this protein) antibody fragments against this protein decrease host cell adhesion and increase transepithelial resistance of human epithelial cell monolayers. Its ability to bind phosphate may allow it to acquire phosphate from its host ; Belongs to the PstS family.
     
 0.843
phoA2
Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family.
     
 0.824
phoU
Phosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family.
     
 0.755
phoR
Two-component sensor PhoR; Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.
     
 0.735
PA5130
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
   
  
 0.731
PA3576
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
      
 0.699
ppx
Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has also polyphosphate:ADP phosphotransferase activity, catalyzing the production of ATP from ADP and polyP.
     
 0.676
PA5208
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
  
  
 0.659
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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