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pprB pprB pprA pprA fppA fppA flp flp rocS1 rocS1 gacS gacS PA0930 PA0930 PA0600 PA0600 PA1243 PA1243 PA0929 PA0929 rpoS rpoS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
pprBTwo-component response regulator, PprB; Member of the two-component regulatory system PprA/PprB involved in biofilm formation by controlling the expression of many related genes including type IVb pili major subunit flp pilin, adhesin bapA or cupE fimbriae. Modulates also quorum-sensing signal production acting on both negative and positive modulators. Functions as a transcription regulator by direct binding to promoter regions. Negatively regulates its own transcription. (275 aa)    
Predicted Functional Partners:
pprA
Two-component sensor PprA; Member of the two-component regulatory system PprA/PprB involved in biofilm formation by controlling the expression of many related genes including type IVb pili major subunit flp pilin, adhesin bapA or cupE fimbriae. Modulates also quorum-sensing signal production acting on both negative and positive modulators. Functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to PprB.
 
 
 0.989
fppA
Flp prepilin peptidase A, FppA; Class 1: Function experimentally demonstrated in P. aeruginosa.
  
  
 0.914
flp
Type IVb pilin, Flp; Class 1: Function experimentally demonstrated in P. aeruginosa.
  
  
 0.876
rocS1
Probable two-component sensor; Class 1: Function experimentally demonstrated in P. aeruginosa.
 
 
 
 0.838
gacS
Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
 
 0.827
PA0930
Two-component sensor; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
 
 
 0.780
PA0600
Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
 
 0.735
PA1243
Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
 
 0.721
PA0929
Two-component response regulator; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
 
 0.704
rpoS
Sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.
   
  
 0.691
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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