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ptsN ptsN ptsH ptsH fruA fruA PA4465 PA4465 PA4463 PA4463 fruK fruK fruI fruI PA3760 PA3760 ptsP ptsP rpoN rpoN PA3761 PA3761
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ptsNNitrogen regulatory IIA protein; Seems to have a role in regulating nitrogen assimilation. (154 aa)    
Predicted Functional Partners:
ptsH
Probable phosphoryl carrier protein; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
 
  
 0.985
fruA
Phosphotransferase system transporter fructose-specific IIBC component, FruA; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
 
  
 0.981
PA4465
Conserved hypothetical protein; Displays ATPase and GTPase activities.
  
  
 0.978
PA4463
Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
 
  
 0.970
fruK
1-phosphofructokinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the carbohydrate kinase PfkB family.
 
  
 0.942
fruI
Phosphotransferase system transporter enzyme I, FruI; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the PEP-utilizing enzyme family.
 
  
 0.923
PA3760
N-Acetyl-D-Glucosamine phosphotransferase system transporter; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
 
  
 0.901
ptsP
Phosphoenolpyruvate-protein phosphotransferase PtsP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the PEP-utilizing enzyme family.
  
  
 0.889
rpoN
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
  
 0.858
PA3761
N-Acetyl-D-Glucosamine phosphotransferase system transporter; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
  
  
 0.808
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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