node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
folD | gcvH1 | PA1796 | PA5214 | 5,10-methylene-tetrahydrofolate dehydrogenase / cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.715 |
folD | gcvP1 | PA1796 | PA5213 | 5,10-methylene-tetrahydrofolate dehydrogenase / cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system protein P1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.706 |
folD | gcvP2 | PA1796 | PA2445 | 5,10-methylene-tetrahydrofolate dehydrogenase / cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system protein P2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.706 |
folD | gcvT1 | PA1796 | PA5215 | 5,10-methylene-tetrahydrofolate dehydrogenase / cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine-cleavage system protein T1; The glycine cleavage system catalyzes the degradation of glycine. | 0.957 |
folD | gcvT2 | PA1796 | PA2442 | 5,10-methylene-tetrahydrofolate dehydrogenase / cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system protein T2; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.948 |
folD | glyA3 | PA1796 | PA4602 | 5,10-methylene-tetrahydrofolate dehydrogenase / cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |
folD | purH | PA1796 | PA4854 | 5,10-methylene-tetrahydrofolate dehydrogenase / cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.977 |
folD | soxA | PA1796 | PA5418 | 5,10-methylene-tetrahydrofolate dehydrogenase / cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Sarcosine oxidase alpha subunit; Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the GcvT family. | 0.666 |
gcvH1 | folD | PA5214 | PA1796 | Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 5,10-methylene-tetrahydrofolate dehydrogenase / cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.715 |
gcvH1 | gcvP1 | PA5214 | PA5213 | Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system protein P1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.999 |
gcvH1 | gcvP2 | PA5214 | PA2445 | Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system protein P2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.999 |
gcvH1 | gcvT1 | PA5214 | PA5215 | Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine-cleavage system protein T1; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH1 | gcvT2 | PA5214 | PA2442 | Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system protein T2; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.999 |
gcvH1 | glyA3 | PA5214 | PA4602 | Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.953 |
gcvH1 | sdaA | PA5214 | PA2443 | Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | L-serine dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.901 |
gcvH1 | sdaB | PA5214 | PA5379 | Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | L-serine dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.522 |
gcvH1 | soxA | PA5214 | PA5418 | Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Sarcosine oxidase alpha subunit; Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the GcvT family. | 0.856 |
gcvP1 | folD | PA5213 | PA1796 | Glycine cleavage system protein P1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 5,10-methylene-tetrahydrofolate dehydrogenase / cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.706 |
gcvP1 | gcvH1 | PA5213 | PA5214 | Glycine cleavage system protein P1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
gcvP1 | gcvP2 | PA5213 | PA2445 | Glycine cleavage system protein P1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | Glycine cleavage system protein P2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. | 0.999 |