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cbrA cbrA cbrB cbrB PA4724.1 PA4724.1 crc crc putA putA rpoN rpoN PA3271 PA3271 ercS-2 ercS-2 ntrC ntrC hfq hfq ercS ercS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cbrATwo-component sensor CbrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (983 aa)    
Predicted Functional Partners:
cbrB
Two-component response regulator CbrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
 
 
 0.993
PA4724.1
Conserved hypothetical protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
 
   
 0.891
crc
Catabolite repression control protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
     
 0.887
putA
Proline dehydrogenase PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
  
  
 0.877
rpoN
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.780
PA3271
Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
 
0.745
ercS-2
ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
 
 0.733
ntrC
Two-component response regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
   
 
 0.733
hfq
Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.
   
  
 0.726
ercS
ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
 
 0.718
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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