STRINGSTRING
panB panB panC panC panD panD panE panE coaC coaC PA1752 PA1752 ilvD ilvD ilvE ilvE panB1 panB1 birA birA folK folK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (266 aa)    
Predicted Functional Partners:
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
 0.999
panD
Aspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
 
  
 0.984
panE
Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
 
  
 0.982
coaC
Phosphopantothenoylcysteine synthase/(R)-4'-phospho-N-pantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
  
 0.932
PA1752
Hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
  
 
 0.917
ilvD
Dihydroxy-acid dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the IlvD/Edd family.
   
 
 0.915
ilvE
Branched-chain amino acid transferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.915
panB1
Conserved hypothetical protein; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
  
  
 
0.912
birA
BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
  
  
 0.635
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the HPPK family.
 
  
 0.624
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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