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fdnG fdnG fdnI fdnI fdnH fdnH fdhE fdhE napF napF PA3628 PA3628 nuoF nuoF selA selA fdhA fdhA kynB kynB purU2 purU2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fdnGFormate dehydrogenase-O, major subunit; Product name confidence: Class 2: Function of highly similar gene experimentally demonstrated in another organism (and gene context consistent in terms of pathways its involved in, if known). (1026 aa)    
Predicted Functional Partners:
fdnI
Nitrate-inducible formate dehydrogenase, gamma subunit; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
 
 0.999
fdnH
Nitrate-inducible formate dehydrogenase, beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.
 
 
 0.999
fdhE
FdhE protein; Necessary for formate dehydrogenase activity. Belongs to the FdhE family.
 
  
 0.945
napF
Ferredoxin protein NapF; Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm; Belongs to the NapF family.
  
 
 0.919
PA3628
Probable esterase; Serine hydrolase involved in the detoxification of formaldehyde.
  
 
  0.911
nuoF
NADH dehydrogenase I chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
  
 
 0.905
selA
L-seryl-tRNA(ser) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
 
  
 0.904
fdhA
Glutathione-independent formaldehyde dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formaldehyde and acetoaldehyde; Belongs to the zinc-containing alcohol dehydrogenase family.
  
 
 0.904
kynB
Kynurenine formamidase, KynB; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation; Belongs to the Cyclase 1 superfamily. KynB family.
    
  0.903
purU2
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
   
 
  0.901
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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