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aruH aruH aruI aruI aruF aruF speA-2 speA-2 ldcA ldcA aruG aruG argH argH arcA arcA dadA dadA gbuA gbuA pheA pheA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
aruHArginine:Pyruvate Transaminase, AruH; Catalyzes the conversion of L-arginine into 2-ketoarginine via transamination. L-arginine is the best substrate, but it can also use L-lysine, L-methionine, L-leucine, ornithine and L-glutamine, which indicates that it may have a broader physiological function in amino acid catabolism. (393 aa)    
Predicted Functional Partners:
aruI
2-ketoarginine decarboxylase, AruI; Catalyzes the decarboxylation of 2-ketoarginine, leading to the formation of 4-guanidinobutyraldehyde.
 
 
 0.997
aruF
Arginine/ornithine succinyltransferase AI subunit; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. Also acts on L-ornithine.
     
 0.975
speA-2
Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
  
 
  0.907
ldcA
Lysine-specific pyridoxal 5'-phosphate-dependent carboxylase, LdcA; Plays an essential role in lysine utilization by acting as a lysine decarboxylase.
     
 0.902
aruG
Arginine/ornithine succinyltransferase AII subunit; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
     
  0.900
argH
Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).
 
 
 0.866
arcA
Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
    
 0.814
dadA
D-amino acid dehydrogenase, small subunit; Catalyzes the oxidative deamination of D-amino acids. Has very broad substrate specificity; all the D-amino acids tested can be used as the substrate except D-Glu and D-Gln. Participates in the utilization of several D-amino acids as the sole source of nitrogen, i.e. D-alanine, D-histidine, D-phenylalanine, D-serine, D-threonine, and D-valine.
      
 0.811
gbuA
Guanidinobutyrase; Catalyzes specifically the hydrolysis of 4-guanidinobutanoate to 4-aminobutanoate and urea. Has no activity against arginine, agmatine, 3-guanidinopropionate and guanidinoacetate.
  
  
 0.766
pheA
Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
 
  
 0.766
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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