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rfaE rfaE gmhA gmhA gmhB gmhB rfaD rfaD waaC waaC waaF waaF waaL waaL galE galE msbA msbA kdsA kdsA PA4995 PA4995
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
rfaELPS biosynthesis protein RfaE; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa)    
Predicted Functional Partners:
gmhA
Sedoheptulose 7-phosphate isomerase GmhA; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily.
 
 0.999
gmhB
Conserved hypothetical protein; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position; Belongs to the GmhB family.
  
 0.997
rfaD
ADP-L-glycero-D-mannoheptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
 
 
 0.997
waaC
Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.983
waaF
Heptosyltransferase II; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.958
waaL
O-antigen ligase, WaaL; Potential O-antigen polymerase, which may be involved in the synthesis of LPS.
     
 0.816
galE
UDP-glucose 4-epimerase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the NAD(P)-dependent epimerase/dehydratase family.
     
 0.786
msbA
Transport protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
 
  
 0.747
kdsA
2-dehydro-3-deoxyphosphooctonate aldolase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the KdsA family.
 
   
 0.740
PA4995
Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
  
  
 0.740
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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