node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | PA5141 | PA5143 | Phosphoribosylformimino-5-aminoimidazole carboxamide; Product name confidence: Class 2 (High similarity to functionally studied protein). | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.999 |
hisA | hisD | PA5141 | PA4448 | Phosphoribosylformimino-5-aminoimidazole carboxamide; Product name confidence: Class 2 (High similarity to functionally studied protein). | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.996 |
hisA | hisE | PA5141 | PA5067 | Phosphoribosylformimino-5-aminoimidazole carboxamide; Product name confidence: Class 2 (High similarity to functionally studied protein). | phosphoribosyl-ATP pyrophosphohydrolase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.993 |
hisA | hisF1 | PA5141 | PA5140 | Phosphoribosylformimino-5-aminoimidazole carboxamide; Product name confidence: Class 2 (High similarity to functionally studied protein). | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.997 |
hisA | hisF2 | PA5141 | PA3151 | Phosphoribosylformimino-5-aminoimidazole carboxamide; Product name confidence: Class 2 (High similarity to functionally studied protein). | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.989 |
hisA | hisG | PA5141 | PA4449 | Phosphoribosylformimino-5-aminoimidazole carboxamide; Product name confidence: Class 2 (High similarity to functionally studied protein). | ATP-phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.996 |
hisA | hisH1 | PA5141 | PA5142 | Phosphoribosylformimino-5-aminoimidazole carboxamide; Product name confidence: Class 2 (High similarity to functionally studied protein). | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.999 |
hisA | hisH2 | PA5141 | PA3152 | Phosphoribosylformimino-5-aminoimidazole carboxamide; Product name confidence: Class 2 (High similarity to functionally studied protein). | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.996 |
hisA | hisI | PA5141 | PA5066 | Phosphoribosylformimino-5-aminoimidazole carboxamide; Product name confidence: Class 2 (High similarity to functionally studied protein). | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | PA5141 | PA4939 | Phosphoribosylformimino-5-aminoimidazole carboxamide; Product name confidence: Class 2 (High similarity to functionally studied protein). | Conserved hypothetical protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). | 0.953 |
hisB | hisA | PA5143 | PA5141 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Phosphoribosylformimino-5-aminoimidazole carboxamide; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.999 |
hisB | hisD | PA5143 | PA4448 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | PA5143 | PA5067 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | phosphoribosyl-ATP pyrophosphohydrolase; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.995 |
hisB | hisF1 | PA5143 | PA5140 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.997 |
hisB | hisF2 | PA5143 | PA3151 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.997 |
hisB | hisG | PA5143 | PA4449 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | ATP-phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.996 |
hisB | hisH1 | PA5143 | PA5142 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity). | 0.999 |
hisB | hisH2 | PA5143 | PA3152 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.996 |
hisB | hisI | PA5143 | PA5066 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.993 |
hisB | hisZ | PA5143 | PA4939 | Imidazoleglycerol-phosphate dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein). | Conserved hypothetical protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). | 0.971 |