node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA0066 | PA5080 | PA0066 | PA5080 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | 0.567 |
PA4908 | PA5080 | PA4908 | PA5080 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | 0.900 |
PA4908 | proC | PA4908 | PA0393 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.922 |
PA4908 | putA | PA4908 | PA0782 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | Proline dehydrogenase PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.949 |
PA5080 | PA0066 | PA5080 | PA0066 | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | 0.567 |
PA5080 | PA4908 | PA5080 | PA4908 | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). | 0.900 |
PA5080 | apaH | PA5080 | PA0590 | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | Bis(5'-nucleosyl)-tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | 0.530 |
PA5080 | dtd | PA5080 | PA5079 | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | Conserved hypothetical protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.839 |
PA5080 | gacA | PA5080 | PA2586 | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. | 0.618 |
PA5080 | gacS | PA5080 | PA0928 | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.640 |
PA5080 | pepP | PA5080 | PA5224 | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.800 |
PA5080 | proC | PA5080 | PA0393 | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.908 |
PA5080 | putA | PA5080 | PA0782 | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | Proline dehydrogenase PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.900 |
PA5080 | rpoS | PA5080 | PA3622 | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | Sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. | 0.614 |
apaH | PA5080 | PA0590 | PA5080 | Bis(5'-nucleosyl)-tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | 0.530 |
dtd | PA5080 | PA5079 | PA5080 | Conserved hypothetical protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | 0.839 |
gacA | PA5080 | PA2586 | PA5080 | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | 0.618 |
gacA | gacS | PA2586 | PA0928 | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. | Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.999 |
gacA | rpoS | PA2586 | PA3622 | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. | Sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. | 0.904 |
gacS | PA5080 | PA0928 | PA5080 | Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). | Prolyl aminopeptidase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S33 family. | 0.640 |