node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
der | guaA | PA3799 | PA3769 | Conserved hypothetical protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.534 |
der | infC | PA3799 | PA2743 | Conserved hypothetical protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | 0.416 |
der | rplA | PA3799 | PA4273 | Conserved hypothetical protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.690 |
der | tig | PA3799 | PA1800 | Conserved hypothetical protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. | 0.474 |
der | tsf | PA3799 | PA3655 | Conserved hypothetical protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity); Belongs to the EF-Ts family. | 0.681 |
der | typA | PA3799 | PA5117 | Conserved hypothetical protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Regulatory protein TypA; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.748 |
der | ychF | PA3799 | PA4673 | Conserved hypothetical protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Conserved hypothetical protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.683 |
gltB | guaA | PA5036 | PA3769 | Glutamate synthase large chain precursor; Product name confidence: Class 2 (High similarity to functionally studied protein). | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.722 |
gltB | rpoB | PA5036 | PA4270 | Glutamate synthase large chain precursor; Product name confidence: Class 2 (High similarity to functionally studied protein). | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.612 |
gltB | typA | PA5036 | PA5117 | Glutamate synthase large chain precursor; Product name confidence: Class 2 (High similarity to functionally studied protein). | Regulatory protein TypA; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.697 |
guaA | der | PA3769 | PA3799 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.534 |
guaA | gltB | PA3769 | PA5036 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Glutamate synthase large chain precursor; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.722 |
guaA | infC | PA3769 | PA2743 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | 0.507 |
guaA | rplA | PA3769 | PA4273 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.918 |
guaA | rplD | PA3769 | PA4262 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). Forms part of the polypeptide exit tunnel; Belongs to the universal ribosomal protein uL4 family. | 0.583 |
guaA | rpoB | PA3769 | PA4270 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.955 |
guaA | tig | PA3769 | PA1800 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. | 0.600 |
guaA | tsf | PA3769 | PA3655 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity); Belongs to the EF-Ts family. | 0.646 |
guaA | typA | PA3769 | PA5117 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Regulatory protein TypA; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.765 |
guaA | ychF | PA3769 | PA4673 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.756 |