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dctD dctD dctB dctB mifS mifS mifR mifR rpoN rpoN PA1336 PA1336 dctA dctA PA2882 PA2882 PA5530 PA5530 pprA pprA PA1243 PA1243
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dctDProbable two-component response regulator; Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. (462 aa)    
Predicted Functional Partners:
dctB
Probable two-component sensor; Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals (By similarity).
 0.999
mifS
MifS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
 0.990
mifR
MifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
  
 
0.910
rpoN
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
  
 0.904
PA1336
Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
 0.886
dctA
C4-dicarboxylate transport protein; Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane.
      
 0.869
PA2882
Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
 
 0.738
PA5530
Probable MFS dicarboxylate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
      
 0.700
pprA
Two-component sensor PprA; Member of the two-component regulatory system PprA/PprB involved in biofilm formation by controlling the expression of many related genes including type IVb pili major subunit flp pilin, adhesin bapA or cupE fimbriae. Modulates also quorum-sensing signal production acting on both negative and positive modulators. Functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to PprB.
 
 
 
 0.666
PA1243
Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
 
 0.664
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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