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phoU phoU pstB pstB pstA pstA pstS pstS pstC pstC phoB phoB phoR phoR phoA2 phoA2 ppx ppx phnC phnC phnE phnE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
phoUPhosphate uptake regulatory protein PhoU; Plays a role in the regulation of phosphate uptake. Belongs to the PhoU family. (242 aa)    
Predicted Functional Partners:
pstB
ATP-binding component of ABC phosphate transporter; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
 
  
 0.999
pstA
Membrane protein component of ABC phosphate transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.999
pstS
Phosphate ABC transporter, periplasmic phosphate-binding protein, PstS; Binds 1 inorganic phosphate per subunit with a KD of 0.34 uM. Required for phosphate transport. In strain PAO1 implicated in host cell adhesion; in some virulent strains (e.g. MDR25 which expresses very high levels of this protein) antibody fragments against this protein decrease host cell adhesion and increase transepithelial resistance of human epithelial cell monolayers. Its ability to bind phosphate may allow it to acquire phosphate from its host ; Belongs to the PstS family.
 
  
 0.996
pstC
Membrane protein component of ABC phosphate transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).
 
  
 0.993
phoB
Two-component response regulator PhoB; This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.
 
  
 0.975
phoR
Two-component sensor PhoR; Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.
 
  
 0.970
phoA2
Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family.
  
  
 0.928
ppx
Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has also polyphosphate:ADP phosphotransferase activity, catalyzing the production of ATP from ADP and polyP.
 
   
 0.794
phnC
ATP-binding component of ABC phosphonate transporter; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
   
  
 0.793
phnE
Phosphonate transport protein PhnE; Product name confidence: Class 2 (High similarity to functionally studied protein).
   
  
 0.781
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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