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betI betI betB betB betA betA betT1 betT1 PA3933 PA3933 PA5291 PA5291 PA3710 PA3710 betC betC cdhC cdhC gbdR gbdR PA5378 PA5378
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Coexpression
Experiments
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[Homology]
Score
betITranscriptional regulator BetI; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity). (197 aa)    
Predicted Functional Partners:
betB
Betaine aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.
  
 0.996
betA
Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
 
  
 0.984
betT1
Choline transporter BetT; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the BCCT transporter (TC 2.A.15) family.
  
  
 0.943
PA3933
Probable choline transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the BCCT transporter (TC 2.A.15) family.
  
  
 0.923
PA5291
Probable choline transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the BCCT transporter (TC 2.A.15) family.
  
  
 0.910
PA3710
Probable GMC-type oxidoreductase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
  
 0.893
betC
Choline sulfatase; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
   
 0.810
cdhC
CdhC, Carnitine dehydrogenase-related protein C; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
  
   
 0.801
gbdR
GbdR; Class 1: Function experimentally demonstrated in P. aeruginosa.
  
   
 0.794
PA5378
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
 
     0.574
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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