node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PA0493 | PA5436 | PA0493 | PA5436 | Probable biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Probable biotin carboxylase subunit of a transcarboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.938 |
PA0493 | accB | PA0493 | PA4847 | Probable biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Biotin carboxyl carrier protein (BCCP); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.450 |
PA0493 | birA | PA0493 | PA4280 | Probable biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.793 |
PA5046 | PA5435 | PA5046 | PA5435 | Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | Probable transcarboxylase subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.938 |
PA5046 | PA5436 | PA5046 | PA5436 | Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | Probable biotin carboxylase subunit of a transcarboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.923 |
PA5046 | aceE | PA5046 | PA5015 | Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.925 |
PA5046 | gltA | PA5046 | PA1580 | Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | Citrate synthase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.850 |
PA5046 | maeA | PA5046 | PA3471 | Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | Probable malic enzyme; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the malic enzymes family. | 0.936 |
PA5046 | ppc | PA5046 | PA3687 | Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. | 0.437 |
PA5435 | PA5046 | PA5435 | PA5046 | Probable transcarboxylase subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.938 |
PA5435 | PA5436 | PA5435 | PA5436 | Probable transcarboxylase subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable biotin carboxylase subunit of a transcarboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.999 |
PA5435 | aceE | PA5435 | PA5015 | Probable transcarboxylase subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.947 |
PA5435 | aceF | PA5435 | PA5016 | Probable transcarboxylase subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.889 |
PA5435 | birA | PA5435 | PA4280 | Probable transcarboxylase subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.895 |
PA5435 | gltA | PA5435 | PA1580 | Probable transcarboxylase subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Citrate synthase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). | 0.948 |
PA5435 | maeA | PA5435 | PA3471 | Probable transcarboxylase subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Probable malic enzyme; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the malic enzymes family. | 0.938 |
PA5435 | ppc | PA5435 | PA3687 | Probable transcarboxylase subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. | 0.969 |
PA5436 | PA0493 | PA5436 | PA0493 | Probable biotin carboxylase subunit of a transcarboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Probable biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.938 |
PA5436 | PA5046 | PA5436 | PA5046 | Probable biotin carboxylase subunit of a transcarboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Malic enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). | 0.923 |
PA5436 | PA5435 | PA5436 | PA5435 | Probable biotin carboxylase subunit of a transcarboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Probable transcarboxylase subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). | 0.999 |