node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PFL_0296 | cysQ | PFL_0296 | PFL_0298 | HAD-superfamily hydrolase, subfamily IA, variant 3; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509. | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. | 0.554 |
PFL_0296 | nudE | PFL_0296 | PFL_0297 | HAD-superfamily hydrolase, subfamily IA, variant 3; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509. | ADP compounds hydrolase NudE; Identified by similarity to SP:P45799; match to protein family HMM PF00293. | 0.542 |
cobA | cysC | PFL_3875 | PFL_0529 | Siroheme synthase/uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.882 |
cobA | cysD-2 | PFL_3875 | PFL_0935 | Siroheme synthase/uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfate adenylyltransferase, small subunit; Identified by similarity to SP:P21156; match to protein family HMM PF01507; match to protein family HMM TIGR02039. | 0.904 |
cobA | cysD-3 | PFL_3875 | PFL_5480 | Siroheme synthase/uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfate adenylyltransferase, small subunit; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. | 0.904 |
cobA | cysH | PFL_3875 | PFL_1854 | Siroheme synthase/uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.932 |
cobA | cysN | PFL_3875 | PFL_0936 | Siroheme synthase/uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Putative sulfate adenylyltransferase, large subunit/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.925 |
cobA | cysNC | PFL_3875 | PFL_5482 | Siroheme synthase/uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfate adenylyltransferase, large subunit/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the APS kinase family. | 0.925 |
cobA | cysQ | PFL_3875 | PFL_0298 | Siroheme synthase/uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. | 0.559 |
cysC | cobA | PFL_0529 | PFL_3875 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Siroheme synthase/uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.882 |
cysC | cysD-2 | PFL_0529 | PFL_0935 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfate adenylyltransferase, small subunit; Identified by similarity to SP:P21156; match to protein family HMM PF01507; match to protein family HMM TIGR02039. | 0.994 |
cysC | cysD-3 | PFL_0529 | PFL_5480 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfate adenylyltransferase, small subunit; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. | 0.994 |
cysC | cysH | PFL_0529 | PFL_1854 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.995 |
cysC | cysN | PFL_0529 | PFL_0936 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Putative sulfate adenylyltransferase, large subunit/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.970 |
cysC | cysNC | PFL_0529 | PFL_5482 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfate adenylyltransferase, large subunit/adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the APS kinase family. | 0.967 |
cysC | cysQ | PFL_0529 | PFL_0298 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. | 0.959 |
cysD-2 | cobA | PFL_0935 | PFL_3875 | Sulfate adenylyltransferase, small subunit; Identified by similarity to SP:P21156; match to protein family HMM PF01507; match to protein family HMM TIGR02039. | Siroheme synthase/uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.904 |
cysD-2 | cysC | PFL_0935 | PFL_0529 | Sulfate adenylyltransferase, small subunit; Identified by similarity to SP:P21156; match to protein family HMM PF01507; match to protein family HMM TIGR02039. | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.994 |
cysD-2 | cysD-3 | PFL_0935 | PFL_5480 | Sulfate adenylyltransferase, small subunit; Identified by similarity to SP:P21156; match to protein family HMM PF01507; match to protein family HMM TIGR02039. | Sulfate adenylyltransferase, small subunit; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. | 0.902 |
cysD-2 | cysH | PFL_0935 | PFL_1854 | Sulfate adenylyltransferase, small subunit; Identified by similarity to SP:P21156; match to protein family HMM PF01507; match to protein family HMM TIGR02039. | Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.938 |