node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PFL_1045 | PFL_1412 | PFL_1045 | PFL_1412 | Identified by match to protein family HMM PF02423. | Proline racemase family protein; Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity. | 0.764 |
PFL_1045 | PFL_1416 | PFL_1045 | PFL_1416 | Identified by match to protein family HMM PF02423. | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | 0.558 |
PFL_1045 | proS | PFL_1045 | PFL_1256 | Identified by match to protein family HMM PF02423. | proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...] | 0.580 |
PFL_1045 | putA | PFL_1045 | PFL_0495 | Identified by match to protein family HMM PF02423. | Proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.492 |
PFL_1412 | PFL_1045 | PFL_1412 | PFL_1045 | Proline racemase family protein; Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity. | Identified by match to protein family HMM PF02423. | 0.764 |
PFL_1412 | PFL_1416 | PFL_1412 | PFL_1416 | Proline racemase family protein; Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity. | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | 0.748 |
PFL_1412 | PFL_2830 | PFL_1412 | PFL_2830 | Proline racemase family protein; Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity. | Aspartate racemase; Identified by match to protein family HMM PF01177; match to protein family HMM TIGR00035; Belongs to the aspartate/glutamate racemases family. | 0.561 |
PFL_1412 | aldH_1 | PFL_1412 | PFL_1415 | Proline racemase family protein; Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity. | NADP-dependent fatty aldehyde dehydrogenase; Identified by similarity to SP:Q56694; match to protein family HMM PF00171. | 0.750 |
PFL_1412 | proS | PFL_1412 | PFL_1256 | Proline racemase family protein; Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity. | proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...] | 0.728 |
PFL_1416 | PFL_1045 | PFL_1416 | PFL_1045 | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | Identified by match to protein family HMM PF02423. | 0.558 |
PFL_1416 | PFL_1412 | PFL_1416 | PFL_1412 | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | Proline racemase family protein; Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity. | 0.748 |
PFL_1416 | PFL_2200 | PFL_1416 | PFL_2200 | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | Identified by match to protein family HMM PF02615; Belongs to the LDH2/MDH2 oxidoreductase family. | 0.910 |
PFL_1416 | PFL_2830 | PFL_1416 | PFL_2830 | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | Aspartate racemase; Identified by match to protein family HMM PF01177; match to protein family HMM TIGR00035; Belongs to the aspartate/glutamate racemases family. | 0.547 |
PFL_1416 | PFL_2905 | PFL_1416 | PFL_2905 | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | Identified by match to protein family HMM PF02615; Belongs to the LDH2/MDH2 oxidoreductase family. | 0.911 |
PFL_1416 | PFL_3827 | PFL_1416 | PFL_3827 | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | Sodium:bile acid symporter family protein; Identified by match to protein family HMM PF01758. | 0.563 |
PFL_1416 | aldH_1 | PFL_1416 | PFL_1415 | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | NADP-dependent fatty aldehyde dehydrogenase; Identified by similarity to SP:Q56694; match to protein family HMM PF00171. | 0.589 |
PFL_1416 | proS | PFL_1416 | PFL_1256 | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...] | 0.444 |
PFL_1416 | putA | PFL_1416 | PFL_0495 | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | Proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.524 |
PFL_1416 | yveA | PFL_1416 | PFL_1414 | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | Aspartate:proton symporter YveA; Identified by similarity to SP:O07002; match to protein family HMM PF00324. | 0.462 |
PFL_2200 | PFL_1416 | PFL_2200 | PFL_1416 | Identified by match to protein family HMM PF02615; Belongs to the LDH2/MDH2 oxidoreductase family. | malate/L-lactate dehydrogenase family protein; Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. May be involved in a degradation pathway that converts trans-3-hydroxy-L- proline (t3LHyp) to L-proline. | 0.910 |