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sulA sulA lexA lexA PFL_0975 PFL_0975 ftsZ ftsZ recN recN PFL_5415 PFL_5415 PFL_0452 PFL_0452 PFL_1749 PFL_1749 PFL_5642 PFL_5642 phaG phaG PFL_1960 PFL_1960
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
sulACell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. (157 aa)    
Predicted Functional Partners:
lexA
LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  
  
 0.885
PFL_0975
YebG family protein; Identified by similarity to SP:P0ACY9; match to protein family HMM PF07130.
  
    0.843
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
    
 
 0.837
recN
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.780
PFL_5415
Putative membrane protein; Identified by match to protein family HMM PF06790.
  
     0.760
PFL_0452
Sporulation and cell division repeat protein; Identified by match to protein family HMM PF05036.
  
     0.756
PFL_1749
Conserved hypothetical protein.
  
     0.753
PFL_5642
Conserved hypothetical protein.
  
     0.743
phaG
(R)-3-hydroxydecanoyl-ACP:CoA transacylase; Identified by similarity to SP:O85207; match to protein family HMM PF00561.
  
     0.741
PFL_1960
Type IV pilus assembly protein, PilZ family; Identified by match to protein family HMM PF07238.
  
     0.738
Your Current Organism:
Pseudomonas protegens
NCBI taxonomy Id: 220664
Other names: P. protegens Pf-5, Pseudomonas fluorescens Pf-5, Pseudomonas protegens Pf-5, Pseudomonas protegens str. Pf-5, Pseudomonas protegens strain Pf-5, Pseudomonas sp. Pf-5
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