node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PFL_1952 | PFL_1953 | PFL_1952 | PFL_1953 | SNF2 family domain/helicase domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. | Conserved hypothetical protein. | 0.780 |
PFL_1952 | PFL_6280 | PFL_1952 | PFL_6280 | SNF2 family domain/helicase domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. | HNH endonuclease domain protein. | 0.700 |
PFL_1952 | dnaN | PFL_1952 | PFL_0002 | SNF2 family domain/helicase domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.728 |
PFL_1952 | mfd | PFL_1952 | PFL_1954 | SNF2 family domain/helicase domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.787 |
PFL_1952 | polA | PFL_1952 | PFL_0082 | SNF2 family domain/helicase domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.823 |
PFL_1952 | recA | PFL_1952 | PFL_1231 | SNF2 family domain/helicase domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.650 |
PFL_1952 | rpoA | PFL_1952 | PFL_5558 | SNF2 family domain/helicase domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.802 |
PFL_1952 | rpoB | PFL_1952 | PFL_5589 | SNF2 family domain/helicase domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.791 |
PFL_1952 | rpoC | PFL_1952 | PFL_5588 | SNF2 family domain/helicase domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.673 |
PFL_1952 | rpoZ | PFL_1952 | PFL_6062 | SNF2 family domain/helicase domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.800 |
PFL_1953 | PFL_1952 | PFL_1953 | PFL_1952 | Conserved hypothetical protein. | SNF2 family domain/helicase domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. | 0.780 |
PFL_1953 | mfd | PFL_1953 | PFL_1954 | Conserved hypothetical protein. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.797 |
PFL_6280 | PFL_1952 | PFL_6280 | PFL_1952 | HNH endonuclease domain protein. | SNF2 family domain/helicase domain protein; Identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434. | 0.700 |
PFL_6280 | dnaN | PFL_6280 | PFL_0002 | HNH endonuclease domain protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.552 |
PFL_6280 | polA | PFL_6280 | PFL_0082 | HNH endonuclease domain protein. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.955 |
PFL_6280 | recA | PFL_6280 | PFL_1231 | HNH endonuclease domain protein. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.511 |
PFL_6280 | rpoA | PFL_6280 | PFL_5558 | HNH endonuclease domain protein. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.950 |
PFL_6280 | rpoB | PFL_6280 | PFL_5589 | HNH endonuclease domain protein. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.952 |
PFL_6280 | rpoC | PFL_6280 | PFL_5588 | HNH endonuclease domain protein. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.803 |
PFL_6280 | rpoZ | PFL_6280 | PFL_6062 | HNH endonuclease domain protein. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.948 |