Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Fusion
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PFL_3826
Transcriptional regulator, AraC family; Identified by match to protein family HMM PF00165; match to protein family HMM PF02311; match to protein family HMM PF07883. (265 aa)
Predicted Functional Partners:
PFL_3827
Sodium:bile acid symporter family protein; Identified by match to protein family HMM PF01758.
0.623
Your Current Organism:
Pseudomonas protegens
NCBI taxonomy Id: 220664 Other names: P. protegens Pf-5, Pseudomonas fluorescens Pf-5, Pseudomonas protegens Pf-5, Pseudomonas protegens str. Pf-5, Pseudomonas protegens strain Pf-5, Pseudomonas sp. Pf-5
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
node1
node2
node1 annotation
node2 annotation
score
PFL_3826
PFL_3827
Transcriptional regulator, AraC family; Identified by match to protein family HMM PF00165; match to protein family HMM PF02311; match to protein family HMM PF07883.
Sodium:bile acid symporter family protein; Identified by match to protein family HMM PF01758.
0.623
PFL_3827
PFL_3826
Sodium:bile acid symporter family protein; Identified by match to protein family HMM PF01758.
Transcriptional regulator, AraC family; Identified by match to protein family HMM PF00165; match to protein family HMM PF02311; match to protein family HMM PF07883.
0.623
Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) disable highlightexplain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: