node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PFL_1453 | iscS | PFL_1453 | PFL_4965 | Conserved hypothetical protein; Identified by match to protein family HMM PF01206; Belongs to the sulfur carrier protein TusA family. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.965 |
PFL_1453 | thiI | PFL_1453 | PFL_0387 | Conserved hypothetical protein; Identified by match to protein family HMM PF01206; Belongs to the sulfur carrier protein TusA family. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.476 |
PFL_1453 | tusA | PFL_1453 | PFL_1931 | Conserved hypothetical protein; Identified by match to protein family HMM PF01206; Belongs to the sulfur carrier protein TusA family. | Sulfurtransferase TusA; Sulfur carrier protein which probably makes part of a sulfur- relay system; Belongs to the sulfur carrier protein TusA family. | 0.908 |
PFL_5157 | iscS | PFL_5157 | PFL_4965 | ThiF/MoeB domain protein; Identified by similarity to SP:P12282; similarity to SP:P30138; match to protein family HMM PF00899; match to protein family HMM PF05237. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.961 |
PFL_5157 | thiI | PFL_5157 | PFL_0387 | ThiF/MoeB domain protein; Identified by similarity to SP:P12282; similarity to SP:P30138; match to protein family HMM PF00899; match to protein family HMM PF05237. | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.526 |
cyaY | fdx | PFL_6010 | PFL_4960 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Ferredoxin, 2Fe-2S type, ISC system; Identified by similarity to SP:P0A9R4; match to protein family HMM PF00111; match to protein family HMM TIGR02007. | 0.906 |
cyaY | hscB | PFL_6010 | PFL_4962 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.906 |
cyaY | iscA | PFL_6010 | PFL_4963 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.576 |
cyaY | iscR | PFL_6010 | PFL_4966 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.403 |
cyaY | iscS | PFL_6010 | PFL_4965 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.931 |
cyaY | iscU | PFL_6010 | PFL_4964 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.985 |
fdx | cyaY | PFL_4960 | PFL_6010 | Ferredoxin, 2Fe-2S type, ISC system; Identified by similarity to SP:P0A9R4; match to protein family HMM PF00111; match to protein family HMM TIGR02007. | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.906 |
fdx | hscB | PFL_4960 | PFL_4962 | Ferredoxin, 2Fe-2S type, ISC system; Identified by similarity to SP:P0A9R4; match to protein family HMM PF00111; match to protein family HMM TIGR02007. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.992 |
fdx | iscA | PFL_4960 | PFL_4963 | Ferredoxin, 2Fe-2S type, ISC system; Identified by similarity to SP:P0A9R4; match to protein family HMM PF00111; match to protein family HMM TIGR02007. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.972 |
fdx | iscR | PFL_4960 | PFL_4966 | Ferredoxin, 2Fe-2S type, ISC system; Identified by similarity to SP:P0A9R4; match to protein family HMM PF00111; match to protein family HMM TIGR02007. | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.836 |
fdx | iscS | PFL_4960 | PFL_4965 | Ferredoxin, 2Fe-2S type, ISC system; Identified by similarity to SP:P0A9R4; match to protein family HMM PF00111; match to protein family HMM TIGR02007. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.958 |
fdx | iscU | PFL_4960 | PFL_4964 | Ferredoxin, 2Fe-2S type, ISC system; Identified by similarity to SP:P0A9R4; match to protein family HMM PF00111; match to protein family HMM TIGR02007. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.989 |
hscB | cyaY | PFL_4962 | PFL_6010 | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.906 |
hscB | fdx | PFL_4962 | PFL_4960 | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Ferredoxin, 2Fe-2S type, ISC system; Identified by similarity to SP:P0A9R4; match to protein family HMM PF00111; match to protein family HMM TIGR02007. | 0.992 |
hscB | iscA | PFL_4962 | PFL_4963 | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.990 |