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aroE-2 aroE-2 aroQ_1 aroQ_1 aroK aroK PFL_4005 PFL_4005 aroE aroE aroQ_2 aroQ_2 quiA quiA pchA pchA PFL_5385 PFL_5385 aroA aroA aroB aroB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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aroE-2Quinate/shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (284 aa)    
Predicted Functional Partners:
aroQ_1
3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
 
 
 0.983
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
 
 0.945
PFL_4005
Shikimate 5-dehydrogenase/quinate 5-dehydrogenase family protein; Identified by match to protein family HMM PF01488; match to protein family HMM PF08501.
  
  
 
0.925
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
  
 
0.921
aroQ_2
3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
  
 
 0.920
quiA
Quinate/shikimate dehydrogenase; Identified by similarity to SP:Q59086; match to protein family HMM PF01011; match to protein family HMM TIGR03074.
     
  0.900
pchA
Isochorismate synthase PchA; Previously identified and characterized. See Youard et al 2007 (PMID: 17938167) for more information; identified by similarity to GB:ABW70804.1; match to protein family HMM PF00425; match to protein family HMM TIGR00543.
  
  
 0.857
PFL_5385
Putative 4-hydroxyphenylpyruvate dioxygenase; Identified by similarity to SP:P80064; match to protein family HMM PF00903; match to protein family HMM PF01261.
 
  
 0.826
aroA
Prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
 0.792
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
  
 0.756
Your Current Organism:
Pseudomonas protegens
NCBI taxonomy Id: 220664
Other names: P. protegens Pf-5, Pseudomonas fluorescens Pf-5, Pseudomonas protegens Pf-5, Pseudomonas protegens str. Pf-5, Pseudomonas protegens strain Pf-5, Pseudomonas sp. Pf-5
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