STRINGSTRING
glcB glcB aceA aceA pta pta gltA gltA PFL_3068 PFL_3068 acsA_1 acsA_1 acsA_2 acsA_2 PFL_4801 PFL_4801 glcF glcF glcD glcD gcl gcl
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)    
Predicted Functional Partners:
aceA
Isocitrate lyase; Identified by match to protein family HMM PF00463; match to protein family HMM TIGR01346.
 
 
 0.994
pta
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.971
gltA
Citrate synthase I; Identified by similarity to SP:P00891; match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family.
   
 0.958
PFL_3068
AMP-binding domain protein; Identified by similarity to SP:P39062; match to protein family HMM PF00501.
   
 0.950
acsA_1
acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.950
acsA_2
acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.950
PFL_4801
Putative fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
 
  
 0.946
glcF
Glycolate oxidase, iron-sulfur subunit; Identified by similarity to SP:P52074; match to protein family HMM PF00037; match to protein family HMM PF02754.
  
 
 0.929
glcD
Glycolate oxidase, subunit GlcD; Identified by similarity to SP:P52075; match to protein family HMM PF01565; match to protein family HMM PF02913; match to protein family HMM TIGR00387.
 
 
 0.928
gcl
Glyoxylate carboligase; Identified by similarity to SP:P30146; match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR01504; Belongs to the TPP enzyme family.
    
 0.927
Your Current Organism:
Pseudomonas protegens
NCBI taxonomy Id: 220664
Other names: P. protegens Pf-5, Pseudomonas fluorescens Pf-5, Pseudomonas protegens Pf-5, Pseudomonas protegens str. Pf-5, Pseudomonas protegens strain Pf-5, Pseudomonas sp. Pf-5
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.