STRINGSTRING
ahcY ahcY metE metE PFL_3511 PFL_3511 metH metH metZ metZ metK metK cysD cysD mdeA mdeA PFL_3013 PFL_3013 PFL_3792 PFL_3792 PFL_3470 PFL_3470
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (469 aa)    
Predicted Functional Partners:
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.972
PFL_3511
Methionine synthase family protein, vitamin-B12 independent; Identified by match to protein family HMM PF01717.
  
 
 0.961
metH
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.956
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
  
 0.946
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
 
 
 0.927
cysD
O-acetylhomoserine sulfhydrylase; Identified by similarity to SP:O13326; match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326.
     
 0.924
mdeA
Methionine gamma-lyase; Identified by similarity to GB:CAA04124.1; match to protein family HMM PF01053; match to protein family HMM PF01212.
  
 0.923
PFL_3013
DNA (cytosine-5-)-methyltransferase; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
     
 0.905
PFL_3792
DNA (cytosine-5-)-methyltransferase; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
     
 0.905
PFL_3470
Putative aminotransferase B; Identified by match to protein family HMM PF00155.
     
  0.900
Your Current Organism:
Pseudomonas protegens
NCBI taxonomy Id: 220664
Other names: P. protegens Pf-5, Pseudomonas fluorescens Pf-5, Pseudomonas protegens Pf-5, Pseudomonas protegens str. Pf-5, Pseudomonas protegens strain Pf-5, Pseudomonas sp. Pf-5
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