node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PFL_3511 | metE | PFL_3511 | PFL_2404 | Methionine synthase family protein, vitamin-B12 independent; Identified by match to protein family HMM PF01717. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.904 |
PFL_3511 | metF | PFL_3511 | PFL_5799 | Methionine synthase family protein, vitamin-B12 independent; Identified by match to protein family HMM PF01717. | Methylenetetrahydrofolate reductase (NAD(P)H); Identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | 0.818 |
PFL_3511 | metH | PFL_3511 | PFL_3662 | Methionine synthase family protein, vitamin-B12 independent; Identified by match to protein family HMM PF01717. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.976 |
folD | gcvT_1 | PFL_3992 | PFL_4643 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase; Identified by match to protein family HMM PF01571; match to protein family HMM PF08669; match to protein family HMM TIGR00528. | 0.947 |
folD | gcvT_2 | PFL_3992 | PFL_5962 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.947 |
folD | glyA_1 | PFL_3992 | PFL_5028 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Identified by similarity to SP:P00477; match to protein family HMM PF00464. | 0.969 |
folD | glyA_2 | PFL_3992 | PFL_5346 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.969 |
folD | glyA_3 | PFL_3992 | PFL_5729 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.969 |
folD | metF | PFL_3992 | PFL_5799 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methylenetetrahydrofolate reductase (NAD(P)H); Identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | 0.943 |
folD | metH | PFL_3992 | PFL_3662 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.769 |
folD | thyA | PFL_3992 | PFL_5895 | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.946 |
gcvT_1 | folD | PFL_4643 | PFL_3992 | Aminomethyltransferase; Identified by match to protein family HMM PF01571; match to protein family HMM PF08669; match to protein family HMM TIGR00528. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.947 |
gcvT_1 | gcvT_2 | PFL_4643 | PFL_5962 | Aminomethyltransferase; Identified by match to protein family HMM PF01571; match to protein family HMM PF08669; match to protein family HMM TIGR00528. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.915 |
gcvT_1 | glyA_1 | PFL_4643 | PFL_5028 | Aminomethyltransferase; Identified by match to protein family HMM PF01571; match to protein family HMM PF08669; match to protein family HMM TIGR00528. | Glycine hydroxymethyltransferase; Identified by similarity to SP:P00477; match to protein family HMM PF00464. | 0.963 |
gcvT_1 | glyA_2 | PFL_4643 | PFL_5346 | Aminomethyltransferase; Identified by match to protein family HMM PF01571; match to protein family HMM PF08669; match to protein family HMM TIGR00528. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.971 |
gcvT_1 | glyA_3 | PFL_4643 | PFL_5729 | Aminomethyltransferase; Identified by match to protein family HMM PF01571; match to protein family HMM PF08669; match to protein family HMM TIGR00528. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.969 |
gcvT_1 | metF | PFL_4643 | PFL_5799 | Aminomethyltransferase; Identified by match to protein family HMM PF01571; match to protein family HMM PF08669; match to protein family HMM TIGR00528. | Methylenetetrahydrofolate reductase (NAD(P)H); Identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | 0.922 |
gcvT_1 | metH | PFL_4643 | PFL_3662 | Aminomethyltransferase; Identified by match to protein family HMM PF01571; match to protein family HMM PF08669; match to protein family HMM TIGR00528. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.956 |
gcvT_1 | thyA | PFL_4643 | PFL_5895 | Aminomethyltransferase; Identified by match to protein family HMM PF01571; match to protein family HMM PF08669; match to protein family HMM TIGR00528. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.916 |
gcvT_2 | folD | PFL_5962 | PFL_3992 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.947 |