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thiG thiG thiS thiS thiO thiO thiE thiE thiC thiC hcnC hcnC thiI thiI thiD thiD dxs dxs PFL_5157 PFL_5157 PFL_4779 PFL_4779
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second shell of interactors
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textmining
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protein homology
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thiGThiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa)    
Predicted Functional Partners:
thiS
Thiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683.
 
 
 0.996
thiO
Glycine oxidase ThiO; Identified by match to protein family HMM PF01266; match to protein family HMM TIGR02352.
 
 0.995
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.974
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
  
 0.969
hcnC
Hydrogen cyanide synthase HcnC; Previously identified and sequenced. See Laville et al 1998 (PMID: 9620970) for more information; identified by similarity to GB:AAC38596.1; match to protein family HMM PF01266.
  
 0.949
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 
 0.947
thiD
Putative phosphomethylpyrimidine kinase; Identified by match to protein family HMM PF08543.
 
  
 0.942
dxs
1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.935
PFL_5157
ThiF/MoeB domain protein; Identified by similarity to SP:P12282; similarity to SP:P30138; match to protein family HMM PF00899; match to protein family HMM PF05237.
 
  
 0.924
PFL_4779
Mutator mutT protein/thiamine monophosphate synthase (TenI); Identified by match to protein family HMM PF00293; match to protein family HMM PF02581; match to protein family HMM TIGR00586.
 
  
 0.884
Your Current Organism:
Pseudomonas protegens
NCBI taxonomy Id: 220664
Other names: P. protegens Pf-5, Pseudomonas fluorescens Pf-5, Pseudomonas protegens Pf-5, Pseudomonas protegens str. Pf-5, Pseudomonas protegens strain Pf-5, Pseudomonas sp. Pf-5
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