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hemC hemC hemD hemD hemB_1 hemB_1 cobA cobA hemB_2 hemB_2 hemE hemE hemA hemA hemL hemL hemX hemX hemY hemY cobM cobM
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protein homology
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hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa)    
Predicted Functional Partners:
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 0.997
hemB_1
Porphobilinogen synthase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family.
 
 0.993
cobA
Siroheme synthase/uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
  
 0.993
hemB_2
Porphobilinogen synthase; Identified by similarity to SP:Q59643; match to protein family HMM PF00490; Belongs to the ALAD family.
 
 0.993
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.985
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.982
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:P48247; match to protein family HMM PF00202; match to protein family HMM TIGR00713.
 
  
 0.904
hemX
HemX protein; Identified by match to protein family HMM PF04375.
  
  
 0.867
hemY
Putative HemY protein; Identified by match to protein family HMM PF07219; match to protein family HMM PF07721.
  
  
 0.819
cobM
Precorrin-4 C(11)-methyltransferase; Identified by similarity to SP:P21922; match to protein family HMM PF00590; match to protein family HMM TIGR01465.
   
 0.792
Your Current Organism:
Pseudomonas protegens
NCBI taxonomy Id: 220664
Other names: P. protegens Pf-5, Pseudomonas fluorescens Pf-5, Pseudomonas protegens Pf-5, Pseudomonas protegens str. Pf-5, Pseudomonas protegens strain Pf-5, Pseudomonas sp. Pf-5
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