node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEA68169.1 | AEA68492.1 | PSEBR_a1946 | PSEBR_a2219 | Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative aminomethyltransferase; Belongs to the GcvT family. | 0.953 |
AEA68169.1 | folD | PSEBR_a1946 | PSEBR_a1812 | Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative bifunctional protein: Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.533 |
AEA68169.1 | folD-2 | PSEBR_a1946 | PSEBR_a2209 | Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative bifunctional protein: methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.756 |
AEA68169.1 | folD-3 | PSEBR_a1946 | PSEBR_a2217 | Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative bifunctional protein: Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.533 |
AEA68169.1 | glyA | PSEBR_a1946 | PSEBR_a3880 | Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase (serine hydroxymethyltransferase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.937 |
AEA68169.1 | glyA-2 | PSEBR_a1946 | PSEBR_a4691 | Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.937 |
AEA68169.1 | glyA-4 | PSEBR_a1946 | PSEBR_a5215 | Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase (serine hydroxymethyltransferase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.937 |
AEA68169.1 | purN | PSEBR_a1946 | PSEBR_a4254 | Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.930 |
AEA68169.1 | purT | PSEBR_a1946 | PSEBR_a4531 | Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
AEA68169.1 | purU-4 | PSEBR_a1946 | PSEBR_a5210 | Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.914 |
AEA68492.1 | AEA68169.1 | PSEBR_a2219 | PSEBR_a1946 | Putative aminomethyltransferase; Belongs to the GcvT family. | Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.953 |
AEA68492.1 | folD | PSEBR_a2219 | PSEBR_a1812 | Putative aminomethyltransferase; Belongs to the GcvT family. | Putative bifunctional protein: Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.937 |
AEA68492.1 | folD-2 | PSEBR_a2219 | PSEBR_a2209 | Putative aminomethyltransferase; Belongs to the GcvT family. | Putative bifunctional protein: methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.937 |
AEA68492.1 | folD-3 | PSEBR_a2219 | PSEBR_a2217 | Putative aminomethyltransferase; Belongs to the GcvT family. | Putative bifunctional protein: Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.966 |
AEA68492.1 | glyA | PSEBR_a2219 | PSEBR_a3880 | Putative aminomethyltransferase; Belongs to the GcvT family. | Glycine hydroxymethyltransferase (serine hydroxymethyltransferase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.941 |
AEA68492.1 | glyA-2 | PSEBR_a2219 | PSEBR_a4691 | Putative aminomethyltransferase; Belongs to the GcvT family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.941 |
AEA68492.1 | glyA-4 | PSEBR_a2219 | PSEBR_a5215 | Putative aminomethyltransferase; Belongs to the GcvT family. | Glycine hydroxymethyltransferase (serine hydroxymethyltransferase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.941 |
AEA68492.1 | purN | PSEBR_a2219 | PSEBR_a4254 | Putative aminomethyltransferase; Belongs to the GcvT family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.916 |
AEA68492.1 | purT | PSEBR_a2219 | PSEBR_a4531 | Putative aminomethyltransferase; Belongs to the GcvT family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.908 |
AEA68492.1 | purU-4 | PSEBR_a2219 | PSEBR_a5210 | Putative aminomethyltransferase; Belongs to the GcvT family. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.914 |