node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEA70692.1 | AEA71814.1 | PSEBR_a4283 | PSEBR_a5313 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. | 0.986 |
AEA70692.1 | PSEBR_a2 | PSEBR_a4283 | PSEBR_a2 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.897 |
AEA70692.1 | dut | PSEBR_a4283 | PSEBR_a5522 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Putative deoxyuridine 5-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.890 |
AEA70692.1 | polA | PSEBR_a4283 | PSEBR_a40 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.839 |
AEA70692.1 | thyA | PSEBR_a4283 | PSEBR_a242 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.910 |
AEA71814.1 | AEA70692.1 | PSEBR_a5313 | PSEBR_a4283 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.986 |
AEA71814.1 | AEA71815.1 | PSEBR_a5313 | PSEBR_a5314 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. | Putative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.963 |
AEA71814.1 | AEA71818.1 | PSEBR_a5313 | PSEBR_a5317 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. | Putative dihydroorotase. | 0.590 |
AEA71814.1 | PSEBR_a2 | PSEBR_a5313 | PSEBR_a2 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.791 |
AEA71814.1 | dut | PSEBR_a5313 | PSEBR_a5522 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. | Putative deoxyuridine 5-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.657 |
AEA71814.1 | gshB | PSEBR_a5313 | PSEBR_a5311 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. | Glutathione synthetase; Belongs to the prokaryotic GSH synthase family. | 0.703 |
AEA71814.1 | polA | PSEBR_a5313 | PSEBR_a40 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.648 |
AEA71814.1 | pyrB | PSEBR_a5313 | PSEBR_a5316 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.627 |
AEA71814.1 | pyrR | PSEBR_a5313 | PSEBR_a5315 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. | Putative uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.620 |
AEA71814.1 | thyA | PSEBR_a5313 | PSEBR_a242 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.576 |
AEA71815.1 | AEA71814.1 | PSEBR_a5314 | PSEBR_a5313 | Putative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. | 0.963 |
AEA71815.1 | AEA71818.1 | PSEBR_a5314 | PSEBR_a5317 | Putative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | Putative dihydroorotase. | 0.625 |
AEA71815.1 | gshB | PSEBR_a5314 | PSEBR_a5311 | Putative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | Glutathione synthetase; Belongs to the prokaryotic GSH synthase family. | 0.621 |
AEA71815.1 | pyrB | PSEBR_a5314 | PSEBR_a5316 | Putative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.628 |
AEA71815.1 | pyrR | PSEBR_a5314 | PSEBR_a5315 | Putative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | Putative uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. | 0.629 |