node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSEEN1373 | dnaA | PSEEN1373 | PSEEN0001 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the DnaA family. HdA subfamily. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.549 |
PSEEN1373 | dnaN | PSEEN1373 | PSEEN0002 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the DnaA family. HdA subfamily. | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.970 |
PSEEN1373 | dnaX | PSEEN1373 | PSEEN1788 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the DnaA family. HdA subfamily. | DNA polymerase III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.422 |
PSEEN1373 | holB | PSEEN1373 | PSEEN1625 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the DnaA family. HdA subfamily. | DNA polymerase III, delta prime subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.403 |
PSEEN1373 | polA | PSEEN1373 | PSEEN0076 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the DnaA family. HdA subfamily. | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.639 |
PSEEN1373 | recF | PSEEN1373 | PSEEN0003 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the DnaA family. HdA subfamily. | DNA replication, recombinaison and repair protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.784 |
PSEEN2767 | dnaN | PSEEN2767 | PSEEN0002 | Putative DNA ligase, ATP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.970 |
PSEEN2767 | holB | PSEEN2767 | PSEEN1625 | Putative DNA ligase, ATP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA polymerase III, delta prime subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.860 |
PSEEN2767 | polA | PSEEN2767 | PSEEN0076 | Putative DNA ligase, ATP-dependent; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.941 |
dnaA | PSEEN1373 | PSEEN0001 | PSEEN1373 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the DnaA family. HdA subfamily. | 0.549 |
dnaA | dnaE | PSEEN0001 | PSEEN4205 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase III, alpha chain; Function of strongly homologous gene; enzyme. | 0.516 |
dnaA | dnaN | PSEEN0001 | PSEEN0002 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.987 |
dnaA | dnaX | PSEEN0001 | PSEEN1788 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.422 |
dnaA | polA | PSEEN0001 | PSEEN0076 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.469 |
dnaA | recF | PSEEN0001 | PSEEN0003 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | DNA replication, recombinaison and repair protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.930 |
dnaE | dnaA | PSEEN4205 | PSEEN0001 | DNA polymerase III, alpha chain; Function of strongly homologous gene; enzyme. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.516 |
dnaE | dnaN | PSEEN4205 | PSEEN0002 | DNA polymerase III, alpha chain; Function of strongly homologous gene; enzyme. | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.978 |
dnaE | dnaQ | PSEEN4205 | PSEEN3558 | DNA polymerase III, alpha chain; Function of strongly homologous gene; enzyme. | DNA polymerase III: epsilon subunit, 3-5 exonucleolytic proofreading function; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. | 0.970 |
dnaE | dnaX | PSEEN4205 | PSEEN1788 | DNA polymerase III, alpha chain; Function of strongly homologous gene; enzyme. | DNA polymerase III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.977 |
dnaE | holA | PSEEN4205 | PSEEN4815 | DNA polymerase III, alpha chain; Function of strongly homologous gene; enzyme. | DNA polymerase III, delta subunit, probably ATP hydrolase; Function of strongly homologous gene; enzyme. | 0.972 |