node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSEEN0026 | def-1 | PSEEN0026 | PSEEN0025 | Putative Smf protein, DNA processing chain A; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; phenotype. | Peptide deformylase 1; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.584 |
PSEEN0026 | fmt | PSEEN0026 | PSEEN0024 | Putative Smf protein, DNA processing chain A; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; phenotype. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.641 |
PSEEN0026 | sun | PSEEN0026 | PSEEN0023 | Putative Smf protein, DNA processing chain A; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; phenotype. | 16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.523 |
PSEEN0026 | tsaC | PSEEN0026 | PSEEN0027 | Putative Smf protein, DNA processing chain A; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; phenotype. | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.741 |
PSEEN1266 | PSEEN4947 | PSEEN1266 | PSEEN4947 | Putative glycoprotein endopeptidase metalloprotease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.953 |
PSEEN1266 | gcp | PSEEN1266 | PSEEN0417 | Putative glycoprotein endopeptidase metalloprotease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.933 |
PSEEN1266 | metG | PSEEN1266 | PSEEN1220 | Putative glycoprotein endopeptidase metalloprotease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.529 |
PSEEN1266 | tsaC | PSEEN1266 | PSEEN0027 | Putative glycoprotein endopeptidase metalloprotease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.677 |
PSEEN4947 | PSEEN1266 | PSEEN4947 | PSEEN1266 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative glycoprotein endopeptidase metalloprotease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.953 |
PSEEN4947 | fmt | PSEEN4947 | PSEEN0024 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.409 |
PSEEN4947 | gcp | PSEEN4947 | PSEEN0417 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.864 |
PSEEN4947 | metG | PSEEN4947 | PSEEN1220 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.503 |
PSEEN4947 | tsaC | PSEEN4947 | PSEEN0027 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.704 |
aroE | metG | PSEEN0031 | PSEEN1220 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.507 |
aroE | tsaC | PSEEN0031 | PSEEN0027 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.482 |
def-1 | PSEEN0026 | PSEEN0025 | PSEEN0026 | Peptide deformylase 1; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | Putative Smf protein, DNA processing chain A; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; phenotype. | 0.584 |
def-1 | fmt | PSEEN0025 | PSEEN0024 | Peptide deformylase 1; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.977 |
def-1 | sun | PSEEN0025 | PSEEN0023 | Peptide deformylase 1; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.758 |
def-1 | tsaC | PSEEN0025 | PSEEN0027 | Peptide deformylase 1; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.515 |
fmt | PSEEN0026 | PSEEN0024 | PSEEN0026 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Putative Smf protein, DNA processing chain A; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; phenotype. | 0.641 |