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thiG thiG PSEEN0306 PSEEN0306 PSEEN4683 PSEEN4683 thiE thiE thiC thiC thiI thiI thiD thiD moeB moeB dxs dxs PSEEN4474 PSEEN4474 hcnC hcnC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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thiGPutative thiamine biosynthesis protein ThiG, thiazole moiety; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (270 aa)    
Predicted Functional Partners:
PSEEN0306
Putative thiamine biosynthesis protein ThiS; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
 
 
 0.996
PSEEN4683
Putative oxidoreductase, FAD-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.
 
 0.995
thiE
Thiamin-phosphate pyrophosphorylase ThiE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.974
thiC
Hydroxymethylpyrimidine moiety synthesis in thiamin biosynthesis; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
  
 0.967
thiI
Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 
 0.949
thiD
Phosphomethylpyrimidine kinase ThiD; Function of strongly homologous gene; enzyme.
 
  
 0.948
moeB
Molybdopterin biosynthesis MoeB protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.943
dxs
1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.933
PSEEN4474
Putative hydrolase MutT/nudix family/Thiamine monophosphate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the Nudix hydrolase family.
 
  
 0.891
hcnC
Hydrogen cyanide synthase HcnC; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.819
Your Current Organism:
Pseudomonas entomophila
NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48
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