node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSEEN0473 | birA | PSEEN0473 | PSEEN0471 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.831 |
PSEEN0473 | coaX | PSEEN0473 | PSEEN0472 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative transcriptional activator; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | 0.805 |
PSEEN1266 | birA | PSEEN1266 | PSEEN0471 | Putative glycoprotein endopeptidase metalloprotease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.929 |
PSEEN3389 | accB | PSEEN3389 | PSEEN4856 | Putative methylcrotonoyl-CoA carboxylase alpha chain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.946 |
PSEEN3389 | birA | PSEEN3389 | PSEEN0471 | Putative methylcrotonoyl-CoA carboxylase alpha chain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.956 |
PSEEN3389 | mccB | PSEEN3389 | PSEEN3387 | Putative methylcrotonoyl-CoA carboxylase alpha chain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 3-methylcrotonyl-CoA carboxylase, beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.999 |
PSEEN3389 | oadA | PSEEN3389 | PSEEN5495 | Putative methylcrotonoyl-CoA carboxylase alpha chain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Oxaloacetate decarboxylase, alpha subunit; Function of strongly homologous gene; enzyme. | 0.995 |
accB | PSEEN3389 | PSEEN4856 | PSEEN3389 | Biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Putative methylcrotonoyl-CoA carboxylase alpha chain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.946 |
accB | accC-1 | PSEEN4856 | PSEEN4857 | Biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Biotin carboxylase (A subunit of acetyl-CoA carboxylase); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.999 |
accB | accC-2 | PSEEN4856 | PSEEN5496 | Biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Biotin carboxylase (A subunit of acetyl-CoA carboxylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.972 |
accB | birA | PSEEN4856 | PSEEN0471 | Biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.852 |
accC-1 | accB | PSEEN4857 | PSEEN4856 | Biotin carboxylase (A subunit of acetyl-CoA carboxylase); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.999 |
accC-1 | birA | PSEEN4857 | PSEEN0471 | Biotin carboxylase (A subunit of acetyl-CoA carboxylase); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.893 |
accC-1 | oadA | PSEEN4857 | PSEEN5495 | Biotin carboxylase (A subunit of acetyl-CoA carboxylase); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Oxaloacetate decarboxylase, alpha subunit; Function of strongly homologous gene; enzyme. | 0.994 |
accC-2 | accB | PSEEN5496 | PSEEN4856 | Biotin carboxylase (A subunit of acetyl-CoA carboxylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.972 |
accC-2 | birA | PSEEN5496 | PSEEN0471 | Biotin carboxylase (A subunit of acetyl-CoA carboxylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.894 |
accC-2 | oadA | PSEEN5496 | PSEEN5495 | Biotin carboxylase (A subunit of acetyl-CoA carboxylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Oxaloacetate decarboxylase, alpha subunit; Function of strongly homologous gene; enzyme. | 0.999 |
bioB | birA | PSEEN5121 | PSEEN0471 | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.956 |
birA | PSEEN0473 | PSEEN0471 | PSEEN0473 | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.831 |
birA | PSEEN1266 | PSEEN0471 | PSEEN1266 | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative glycoprotein endopeptidase metalloprotease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. | 0.929 |