node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSEEN4069 | iscS-1 | PSEEN4069 | PSEEN1010 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the sulfur carrier protein TusA family. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.969 |
PSEEN4069 | thiI | PSEEN4069 | PSEEN0391 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the sulfur carrier protein TusA family. | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.487 |
PSEEN4069 | tusA | PSEEN4069 | PSEEN3754 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the sulfur carrier protein TusA family. | Conserved hypothetical protein; Sulfur carrier protein which probably makes part of a sulfur- relay system; Belongs to the sulfur carrier protein TusA family. | 0.906 |
cyaY | fdx | PSEEN5363 | PSEEN1015 | Conserved hypothetical protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Ferredoxin, 2Fe-2S type, ISC system; Function of homologous gene experimentally demonstrated in an other organism; carrier. | 0.848 |
cyaY | hscB | PSEEN5363 | PSEEN1013 | Conserved hypothetical protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.847 |
cyaY | iscA | PSEEN5363 | PSEEN1012 | Conserved hypothetical protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.577 |
cyaY | iscS-1 | PSEEN5363 | PSEEN1010 | Conserved hypothetical protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.922 |
cyaY | iscU | PSEEN5363 | PSEEN1011 | Conserved hypothetical protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Iron-sulfur cluster assembly protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.980 |
cyaY | thiI | PSEEN5363 | PSEEN0391 | Conserved hypothetical protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.466 |
fdx | cyaY | PSEEN1015 | PSEEN5363 | Ferredoxin, 2Fe-2S type, ISC system; Function of homologous gene experimentally demonstrated in an other organism; carrier. | Conserved hypothetical protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.848 |
fdx | hscB | PSEEN1015 | PSEEN1013 | Ferredoxin, 2Fe-2S type, ISC system; Function of homologous gene experimentally demonstrated in an other organism; carrier. | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.987 |
fdx | iscA | PSEEN1015 | PSEEN1012 | Ferredoxin, 2Fe-2S type, ISC system; Function of homologous gene experimentally demonstrated in an other organism; carrier. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.972 |
fdx | iscR | PSEEN1015 | PSEEN1009 | Ferredoxin, 2Fe-2S type, ISC system; Function of homologous gene experimentally demonstrated in an other organism; carrier. | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.775 |
fdx | iscS-1 | PSEEN1015 | PSEEN1010 | Ferredoxin, 2Fe-2S type, ISC system; Function of homologous gene experimentally demonstrated in an other organism; carrier. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.973 |
fdx | iscU | PSEEN1015 | PSEEN1011 | Ferredoxin, 2Fe-2S type, ISC system; Function of homologous gene experimentally demonstrated in an other organism; carrier. | Iron-sulfur cluster assembly protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.990 |
hscB | cyaY | PSEEN1013 | PSEEN5363 | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Conserved hypothetical protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.847 |
hscB | fdx | PSEEN1013 | PSEEN1015 | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Ferredoxin, 2Fe-2S type, ISC system; Function of homologous gene experimentally demonstrated in an other organism; carrier. | 0.987 |
hscB | iscA | PSEEN1013 | PSEEN1012 | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.989 |
hscB | iscR | PSEEN1013 | PSEEN1009 | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.927 |
hscB | iscS-1 | PSEEN1013 | PSEEN1010 | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.975 |