STRINGSTRING
aprF aprF aprD aprD aprE aprE aprA aprA aprI aprI PSEEN2195 PSEEN2195 hasE hasE macB macB macB2 macB2 PSEEN2176 PSEEN2176 PSEEN5322 PSEEN5322
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
aprFAlkaline protease (aprA) secretion protein aprF; Function of homologous gene experimentally demonstrated in an other organism; transporter. (449 aa)    
Predicted Functional Partners:
aprD
Alkaline protease (aprA) secretion protein aprD; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.940
aprE
Alkaline protease (aprA) secretion protein aprE; Function of homologous gene experimentally demonstrated in an other organism; transporter.
 
 
 0.926
aprA
Alkaline metalloprotease precursor AprA; Secreted protease which is important for P.entomophila to counteract the local immune response of Drosophila. Can degrade antimicrobial peptides (AMPs), e.g. Diptericin and Cecropin A. Thus, protects P.entomophila from the Drosophila antimicrobial peptides produced by the gut innate immune response, and promotes bacterial persistence in the Drosophila gut and killing of the host. Is responsible for maturation of pro-Monalysin to the active toxin Monalysin, by cleaving its N-terminus ; Belongs to the peptidase M10B family.
 
  
 0.860
aprI
Inhibitor of protease aprA; Function of homologous gene experimentally demonstrated in an other organism; factor.
  
  
 0.838
PSEEN2195
Triacylglycerol lipase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.665
hasE
Heme acquisition transporter, membrane fusion protein HasE; Function of homologous gene experimentally demonstrated in an other organism; transporter.
 
 
 0.658
macB
Macrolide ABC efflux protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.594
macB2
Putative efflux ABC transporter, ATP-binding/permease protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.594
PSEEN2176
Putative activation/secretion protein, TPS family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter.
  
  
 0.546
PSEEN5322
Putative membrane fusion protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter.
 
 
 0.537
Your Current Organism:
Pseudomonas entomophila
NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48
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