node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSEEN1997 | PSEEN2620 | PSEEN1997 | PSEEN2620 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative excinuclease ABC, UvrA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.578 |
PSEEN1997 | gyrA | PSEEN1997 | PSEEN1487 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA gyrase, subunit A, type II topoisomerase; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP- [...] | 0.443 |
PSEEN1997 | gyrB | PSEEN1997 | PSEEN0004 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.697 |
PSEEN1997 | mfd | PSEEN1997 | PSEEN3715 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Transcription-repair coupling protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.411 |
PSEEN1997 | polA | PSEEN1997 | PSEEN0076 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.972 |
PSEEN1997 | uvrA | PSEEN1997 | PSEEN0519 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA excision repair enzyme subunit, with UvrBC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.578 |
PSEEN1997 | uvrB | PSEEN1997 | PSEEN1636 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Exonuclease ABC subunit B (ATP-dependent DNA excision repair enzyme UvrAC); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If [...] | 0.708 |
PSEEN1997 | uvrC | PSEEN1997 | PSEEN3449 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.659 |
PSEEN1997 | uvrD | PSEEN1997 | PSEEN5504 | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA-dependent ATPase I and helicase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.503 |
PSEEN2619 | PSEEN2620 | PSEEN2619 | PSEEN2620 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative excinuclease ABC, UvrA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.603 |
PSEEN2620 | PSEEN1997 | PSEEN2620 | PSEEN1997 | Putative excinuclease ABC, UvrA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative ATP-dependent DNA helicase, RecQ-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.578 |
PSEEN2620 | PSEEN2619 | PSEEN2620 | PSEEN2619 | Putative excinuclease ABC, UvrA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.603 |
PSEEN2620 | gyrA | PSEEN2620 | PSEEN1487 | Putative excinuclease ABC, UvrA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA gyrase, subunit A, type II topoisomerase; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP- [...] | 0.580 |
PSEEN2620 | gyrB | PSEEN2620 | PSEEN0004 | Putative excinuclease ABC, UvrA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.581 |
PSEEN2620 | mfd | PSEEN2620 | PSEEN3715 | Putative excinuclease ABC, UvrA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Transcription-repair coupling protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.764 |
PSEEN2620 | polA | PSEEN2620 | PSEEN0076 | Putative excinuclease ABC, UvrA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.613 |
PSEEN2620 | uvrA | PSEEN2620 | PSEEN0519 | Putative excinuclease ABC, UvrA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA excision repair enzyme subunit, with UvrBC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.911 |
PSEEN2620 | uvrB | PSEEN2620 | PSEEN1636 | Putative excinuclease ABC, UvrA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Exonuclease ABC subunit B (ATP-dependent DNA excision repair enzyme UvrAC); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If [...] | 0.981 |
PSEEN2620 | uvrC | PSEEN2620 | PSEEN3449 | Putative excinuclease ABC, UvrA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.829 |
PSEEN2620 | uvrD | PSEEN2620 | PSEEN5504 | Putative excinuclease ABC, UvrA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA-dependent ATPase I and helicase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.601 |